TCF7L1
transcription factor 7 like 1
Summary
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]
Known Variants63 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1291184134 | 2:85,360,812 | C/A | — | uncertain significance |
| rs1334136297 | 2:85,360,814 | C/A | — | uncertain significance |
| rs534725385 | 2:85,360,841 | G/A | — | likely benign |
| rs867365963 | 2:85,360,850 | A/G | — | uncertain significance |
| rs1365627777 | 2:85,360,857 | G/A | — | uncertain significance |
| rs2528229012 | 2:85,360,871 | A/G | — | likely benign |
| rs1401924140 | 2:85,360,916 | G/A | — | uncertain significance |
| rs553066847 | 2:85,360,949 | G/C | — | uncertain significance |
| rs371552956 | 2:85,360,970 | A/G | — | uncertain significance |
| rs1056768261 | 2:85,360,997 | G/A | — | uncertain significance |
| rs201679633 | 2:85,361,146 | G/C | — | uncertain significance |
| rs376401396 | 2:85,361,454 | C/T | — | uncertain significance |
| rs369924732 | 2:85,361,490 | C/T | — | uncertain significance |
| rs11126983 | 2:85,429,198 | G/C | — | — |
| rs6709476 | 2:85,443,924 | G/A | intron variant | — |
| rs528216365 | 2:85,449,079 | A/G | — | — |
| rs74418251 | 2:85,459,175 | G/A | regulatory region variant | — |
| rs2043230 | 2:85,483,350 | A/T | regulatory region variant | — |
| rs11904127 | 2:85,484,818 | G/A | regulatory region variant | — |
| rs2366264 | 2:85,489,011 | G/T | downstream gene variant | — |
| rs11126989 | 2:85,490,112 | T/A | upstream gene variant | — |
| rs144948309 | 2:85,497,384 | G/T | regulatory region variant | — |
| rs62162674 | 2:85,502,236 | G/C | intron variant | — |
| rs10180579 | 2:85,507,788 | A/C | — | — |
| rs34644194 | 2:85,510,400 | A/G | — | benign |
| rs7601117 | 2:85,510,425 | A/G | — | benign |
| rs927701240 | 2:85,510,646 | A/C | — | uncertain significance |
| rs115942112 | 2:85,510,654 | T/A | — | benign |
| rs2528488289 | 2:85,510,674 | C/G | — | uncertain significance |
| rs887183575 | 2:85,510,675 | A/C | — | uncertain significance |
| rs35802950 | 2:85,510,676 | C/T | — | uncertain significance |
| rs1681474023 | 2:85,510,688 | C/G | — | uncertain significance |
| rs7574856 | 2:85,510,777 | A/G | — | benign |
| rs7574999 | 2:85,510,965 | A/G | — | benign |
| rs188552733 | 2:85,512,760 | C/T | regulatory region variant | — |
| rs56339562 | 2:85,517,448 | A/G | intron variant | — |
| rs140884795 | 2:85,527,772 | G/C | regulatory region variant | — |
| rs13001442 | 2:85,529,981 | A/G | — | benign |
| rs13033165 | 2:85,530,065 | C/T | — | benign |
| rs766809838 | 2:85,531,054 | C/T | — | uncertain significance |
| rs148978980 | 2:85,531,069 | C/G | — | uncertain significance |
| rs11900333 | 2:85,531,579 | A/C | — | benign |
| rs6741339 | 2:85,532,205 | C/G | — | benign |
| rs200127157 | 2:85,532,424 | C/G | — | uncertain significance |
| rs144957884 | 2:85,532,468 | G/A | — | uncertain significance |
| rs200382325 | 2:85,532,525 | G/A | — | uncertain significance |
| rs866438305 | 2:85,533,633 | G/A | — | uncertain significance |
| rs543942730 | 2:85,534,062 | C/T | — | — |
| rs554024559 | 2:85,535,521 | T/C | — | — |
| rs72936604 | 2:85,535,540 | T/C | intron variant | — |
| rs542009262 | 2:85,536,235 | G/A | — | uncertain significance |
| rs1472653101 | 2:85,536,244 | C/A | — | uncertain significance |
| rs141268521 | 2:85,536,276 | G/A | — | likely benign |
| rs41289945 | 2:85,536,352 | C/T | — | uncertain significance |
| rs746848099 | 2:85,536,389 | C/T | — | uncertain significance |
| rs774555974 | 2:85,536,409 | T/C | — | uncertain significance |
| rs761148032 | 2:85,536,432 | G/T | — | uncertain significance |
| rs894997759 | 2:85,536,469 | A/C | — | uncertain significance |
| rs777197590 | 2:85,536,497 | C/T | — | uncertain significance |
| rs140544946 | 2:85,536,499 | T/C | — | uncertain significance |
| rs567718768 | 2:85,536,545 | A/G | — | uncertain significance |
| rs776964872 | 2:85,536,554 | C/G | — | uncertain significance |
| rs148891234 | 2:85,536,565 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.