THEM4

thioesterase superfamily member 4

Summary

Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]

Known Variants25 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs2338201	1:151,845,650	G/A	—	—
rs34876655	1:151,846,839	A/C	—	—
rs146012344	1:151,849,481	C/T	—	likely benign
rs199652573	1:151,849,551	A/G	—	uncertain significance
rs192107051	1:151,849,555	T/C	—	uncertain significance
rs770353180	1:151,849,597	T/C	—	uncertain significance
rs201025062	1:151,849,599	G/A	—	uncertain significance
rs6685187	1:151,858,888	A/G	intron variant	—
rs6698740	1:151,859,050	G/A	intron variant	—
rs1335403752	1:151,860,817	A/G	—	likely benign
rs765404193	1:151,861,766	C/T	—	uncertain significance
rs73009658	1:151,861,842	C/G	—	benign
rs1060870	1:151,862,661	G/C	—	—
rs114800758	1:151,867,528	C/T	—	benign
rs774051084	1:151,867,546	C/T	—	uncertain significance
rs200698202	1:151,867,558	C/T	—	uncertain significance
rs1349474960	1:151,867,614	G/C	—	uncertain significance
rs761138464	1:151,867,631	A/C	—	likely benign
rs201767984	1:151,867,651	T/C	—	uncertain significance
rs7542137	1:151,868,892	C/T	intron variant	—
rs778343849	1:151,881,850	G/A	—	uncertain significance
rs1173180309	1:151,881,853	C/T	—	uncertain significance
rs1054035476	1:151,881,924	C/G	—	uncertain significance
rs771668983	1:151,881,925	T/C	—	uncertain significance
rs10788817	1:151,882,856	C/T	—	—

Gene information from NCBI Gene. Variant classifications from ClinVar.