rs761138464
This variant is located in the THEM4 gene.
▶ClinVar annotation
About THEM4
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]
View all THEM4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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