THOC2

THO complex subunit 2

Summary

The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.[provided by RefSeq, Jun 2010]

Known Variants172 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs2473181	X:122,735,221	G/C	upstream gene variant	—
rs369296561	X:122,744,802	C/T	—	benign
rs752066937	X:122,744,803	G/A	—	uncertain significance
rs775680174	X:122,744,813	G/A	—	likely benign
rs2520689062	X:122,745,348	T/C	—	uncertain significance
rs1474472931	X:122,747,263	G/A	—	uncertain significance
rs1603229932	X:122,747,281	T/C	—	uncertain significance
rs2520737068	X:122,747,284	T/G	—	uncertain significance
rs2147547261	X:122,747,302	C/G	—	uncertain significance
rs2046785257	X:122,747,487	T/C	—	uncertain significance
rs987969946	X:122,747,511	G/A	—	uncertain significance
rs1556005930	X:122,747,561	T/C	—	pathogenic
rs191054518	X:122,747,893	T/A	—	benign
rs2147550123	X:122,747,914	C/G	—	uncertain significance
rs922460485	X:122,747,921	G/C	—	uncertain significance
rs2520758663	X:122,747,949	C/T	—	uncertain significance
rs367878305	X:122,748,014	T/C	—	likely benign
rs2147550641	X:122,748,016	G/A	—	uncertain significance
rs2520760844	X:122,748,024	G/A	—	uncertain significance
rs2520761167	X:122,748,034	T/C	—	uncertain significance
rs866352621	X:122,754,804	C/T	—	uncertain significance
rs2520919257	X:122,754,807	C/T	—	uncertain significance
rs183230381	X:122,754,824	G/A	—	benign
rs780827356	X:122,755,009	C/T	—	benign
rs780690081	X:122,755,044	G/A	—	uncertain significance
rs1222842994	X:122,755,055	G/A	—	uncertain significance
rs1483498582	X:122,755,089	C/A	—	uncertain significance
rs143837850	X:122,755,179	C/T	—	benign
rs1339252599	X:122,755,191	T/C	—	uncertain significance
rs866093948	X:122,755,215	C/T	—	uncertain significance
rs1458661447	X:122,755,259	G/A	—	uncertain significance
rs372924579	X:122,755,305	G/A	—	uncertain significance
rs1556014537	X:122,756,613	T/G	—	uncertain significance
rs2147594705	X:122,756,621	C/T	—	uncertain significance
rs2047134304	X:122,756,624	T/G	—	uncertain significance
rs1666536676	X:122,757,012	G/A	—	uncertain significance
rs753209373	X:122,757,025	C/G	—	uncertain significance
rs1248505410	X:122,757,060	G/T	—	uncertain significance
rs1556014935	X:122,757,079	G/A	—	pathogenic
rs2520974618	X:122,757,103	A/G	—	uncertain significance
rs1569335121	X:122,757,130	A/G	—	uncertain significance
rs186145610	X:122,757,141	G/A	—	benign
rs1556015437	X:122,757,634	T/G	—	likely pathogenic
rs2047169812	X:122,757,714	C/T	—	uncertain significance
rs141055699	X:122,757,715	T/C	—	benign
rs1556015553	X:122,757,780	T/C	—	uncertain significance
rs2520992498	X:122,757,800	G/C	—	uncertain significance
rs2147599772	X:122,757,815	A/G	—	uncertain significance
rs375768878	X:122,757,817	C/T	—	likely benign
rs1556015593	X:122,757,818	G/A	—	likely pathogenic
rs909269528	X:122,757,903	T/C	—	uncertain significance
rs2047177327	X:122,757,924	T/C	—	likely pathogenic
rs1603242447	X:122,757,929	C/A	—	uncertain significance
rs1556015763	X:122,757,987	C/T	—	uncertain significance
rs1603242504	X:122,758,006	G/A	—	uncertain significance
rs2520998699	X:122,758,041	T/C	—	uncertain significance
rs2521010181	X:122,758,441	A/G	—	uncertain significance
rs190465904	X:122,758,461	G/A	—	benign
rs2521010794	X:122,758,465	C/T	—	uncertain significance
rs2521010862	X:122,758,468	C/T	—	uncertain significance
rs1316746922	X:122,758,526	G/T	—	uncertain significance
rs2072914	X:122,758,529	G/A	—	benign
rs2521042911	X:122,759,782	G/A	—	uncertain significance
rs797045020	X:122,759,786	A/G	missense variant	pathogenic
rs1326074013	X:122,759,827	C/T	—	uncertain significance
rs2521043568	X:122,759,828	G/A	—	uncertain significance
rs1481091609	X:122,759,837	A/G	—	uncertain significance
rs1556017474	X:122,759,878	C/T	—	uncertain significance
rs1403304532	X:122,760,401	T/C	—	uncertain significance
rs2521055640	X:122,760,453	C/T	—	likely pathogenic
rs2521056003	X:122,760,483	G/A	—	likely pathogenic
rs768889900	X:122,761,559	A/G	—	likely benign
rs201952458	X:122,761,564	T/C	—	benign
rs1256411821	X:122,761,567	C/G	—	uncertain significance
rs991073315	X:122,761,581	T/C	—	uncertain significance
rs2147617004	X:122,761,606	A/G	—	likely pathogenic
rs2147617020	X:122,761,617	G/T	—	uncertain significance
rs2047319309	X:122,761,629	T/C	—	uncertain significance
rs1383713265	X:122,761,631	A/G	—	likely benign
rs2521078885	X:122,761,646	C/A	—	uncertain significance
rs1603246794	X:122,761,659	T/C	—	likely pathogenic
rs765209194	X:122,761,703	G/A	—	likely benign
rs780461608	X:122,765,497	T/C	—	benign
rs769718049	X:122,765,606	T/C	—	uncertain significance
rs797045021	X:122,765,621	A/G	missense variant	pathogenic
rs2521162548	X:122,765,622	T/C	—	uncertain significance
rs2521163204	X:122,765,654	C/T	—	uncertain significance
rs368394995	X:122,765,665	T/C	—	likely benign
rs3764750	X:122,765,750	T/C	—	benign
rs979471831	X:122,766,719	T/C	—	uncertain significance
rs373608603	X:122,766,721	G/C	—	likely benign
rs2521190540	X:122,766,818	T/C	—	uncertain significance
rs2521191305	X:122,766,851	G/A	—	uncertain significance
rs1603252573	X:122,766,858	T/C	—	uncertain significance
rs1556023928	X:122,766,890	C/T	—	pathogenic
rs1556024875	X:122,767,853	G/A	—	pathogenic
rs2521214896	X:122,767,875	T/C	—	uncertain significance
rs772002677	X:122,767,926	T/A	—	likely benign
rs772962258	X:122,767,927	C/T	—	likely benign
rs1239381361	X:122,769,938	C/T	—	likely benign

Showing 100 of 172 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.