THSD4

thrombospondin type 1 domain containing 4

Summary

Predicted to enable hydrolase activity. Predicted to be an extracellular matrix structural constituent. Involved in microfibril assembly. Located in microfibril. Implicated in thoracic aortic aneurysm. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants134 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs55692105	15:71,390,682	G/T	—	—
rs12904863	15:71,424,009	T/G	—	—
rs199775974	15:71,433,891	C/G	—	uncertain significance
rs374434657	15:71,447,239	G/A	—	uncertain significance
rs4777336	15:71,473,310	G/T	—	—
rs2542980172	15:71,507,375	T/A	—	uncertain significance
rs368500845	15:71,507,377	C/T	—	uncertain significance
rs2542980294	15:71,507,402	C/T	—	uncertain significance
rs1202293855	15:71,507,429	C/T	—	uncertain significance
rs2542980545	15:71,507,449	T/G	—	uncertain significance
rs150014427	15:71,507,457	C/T	—	benign
rs772153867	15:71,507,521	C/G	—	likely benign
rs1490765758	15:71,507,546	A/G	—	uncertain significance
rs746860013	15:71,507,554	G/A	—	likely benign
rs112104417	15:71,507,556	C/T	—	benign
rs78239928	15:71,507,565	G/A	—	benign
rs12914419	15:71,507,603	C/T	—	uncertain significance
rs1163419529	15:71,507,620	C/G	—	uncertain significance
rs918773785	15:71,507,702	C/T	—	uncertain significance
rs930116181	15:71,507,713	G/T	—	conflicting classifications of pathogenicity
rs751589218	15:71,535,029	A/G	—	uncertain significance
rs1389129595	15:71,535,071	C/T	—	uncertain significance
rs200233214	15:71,535,077	C/T	—	likely benign
rs751624116	15:71,535,101	A/C	—	uncertain significance
rs771585103	15:71,535,143	C/A	—	uncertain significance
rs748660152	15:71,535,173	A/G	—	uncertain significance
rs368631099	15:71,535,189	G/A	—	likely benign
rs375872892	15:71,535,218	G/A	—	uncertain significance
rs374099396	15:71,535,236	C/T	—	conflicting classifications of pathogenicity
rs377400944	15:71,535,237	G/A	—	likely benign
rs369887663	15:71,535,326	A/G	—	likely benign
rs778201542	15:71,535,380	C/G	—	uncertain significance
rs754604397	15:71,535,436	G/A	—	uncertain significance
rs774987583	15:71,548,994	G/T	—	uncertain significance
rs2140288609	15:71,549,000	T/A	—	pathogenic
rs756295653	15:71,549,043	C/A	—	uncertain significance
rs76917273	15:71,572,954	T/C	intron variant	—
rs9806183	15:71,574,799	G/A	—	—
rs1442779	15:71,576,755	A/C	—	—
rs1606887	15:71,605,432	T/A	—	—
rs11631778	15:71,606,380	G/A	regulatory region variant	—
rs17786786	15:71,608,619	A/C	intron variant	—
rs12899618	15:71,645,120	G/A	downstream gene variant	—
rs9672719	15:71,661,106	C/G	intron variant	—
rs2044029	15:71,679,959	A/T	—	—
rs12441227	15:71,696,886	A/G	intron variant	—
rs781436484	15:71,704,085	C/T	—	uncertain significance
rs776054240	15:71,704,130	G/A	—	uncertain significance
rs550641964	15:71,754,083	C/A	—	—
rs62015884	15:71,804,587	C/T	intron variant	—
rs117286812	15:71,839,803	A/G	—	benign
rs185663502	15:71,943,833	A/G	intron variant	—
rs17797245	15:71,945,128	T/A	—	—
rs78622229	15:71,952,882	A/G	—	uncertain significance
rs1397217530	15:71,952,890	T/A	—	uncertain significance
rs72742760	15:71,952,899	A/G	—	benign
rs762902000	15:71,952,918	G/A	—	uncertain significance
rs142908915	15:71,952,942	C/A	—	uncertain significance
rs202063075	15:71,952,945	G/C	—	uncertain significance
rs2051284379	15:71,952,959	T/A	—	uncertain significance
rs1460578316	15:71,953,028	A/C	—	uncertain significance
rs749428270	15:71,953,029	C/T	—	uncertain significance
rs62024298	15:71,953,045	G/A	—	benign
rs2051288341	15:71,953,059	G/A	—	uncertain significance
rs150525643	15:72,020,921	A/G	—	uncertain significance
rs754247111	15:72,021,002	C/G	—	uncertain significance
rs780022155	15:72,021,013	G/A	—	uncertain significance
rs770575341	15:72,021,058	G/A	—	uncertain significance
rs2052914931	15:72,021,064	G/C	—	likely pathogenic
rs73430294	15:72,021,071	T/C	—	benign
rs773494479	15:72,023,466	C/T	—	uncertain significance
rs757426255	15:72,023,501	C/T	—	likely benign
rs138125166	15:72,023,502	G/A	—	conflicting classifications of pathogenicity
rs771661487	15:72,023,521	C/T	—	uncertain significance
rs369493146	15:72,023,533	A/G	—	uncertain significance
rs763293735	15:72,023,539	C/T	—	uncertain significance
rs549767941	15:72,023,802	G/T	—	—
rs7172787	15:72,030,066	C/T	—	benign
rs200317870	15:72,030,141	C/A	—	conflicting classifications of pathogenicity
rs185781006	15:72,030,142	G/A	—	uncertain significance
rs767052532	15:72,030,160	C/T	—	uncertain significance
rs200169944	15:72,030,161	G/A	—	likely benign
rs77964295	15:72,030,194	C/T	—	benign
rs199561497	15:72,030,242	G/A	—	uncertain significance
rs368102867	15:72,030,245	C/T	—	uncertain significance
rs202043198	15:72,030,269	C/T	—	likely benign
rs902079951	15:72,030,278	C/G	—	uncertain significance
rs199993875	15:72,030,290	G/A	—	uncertain significance
rs201126760	15:72,030,299	A/G	—	uncertain significance
rs771776748	15:72,030,332	C/T	—	likely benign
rs375173523	15:72,030,333	G/A	—	likely benign
rs200113852	15:72,037,481	G/C	—	benign
rs28691775	15:72,037,495	G/T	—	benign
rs1214737874	15:72,037,515	C/G	—	uncertain significance
rs965774203	15:72,037,529	C/T	—	uncertain significance
rs778434072	15:72,037,560	C/A	—	uncertain significance
rs1288006880	15:72,037,581	A/G	—	uncertain significance
rs2543122625	15:72,039,212	C/G	—	uncertain significance
rs376870646	15:72,039,352	G/A	—	uncertain significance
rs146042172	15:72,039,380	C/T	—	conflicting classifications of pathogenicity

Showing 100 of 134 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.