rs11631778
This is a regulatory region variant variant in the THSD4 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Microscopic hematuria
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.07
p 2.0e-14
N 616,716
Major Consortium StudyLarge GWAS
multi-ancestry
diastolic blood pressure
Hoffmann TJ et al. “Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.” Nature Genetics 49(1):54-64 (2017)
Allele G
OR 0.14
p 1.0e-8
N 321,262
Large GWAS
multi-ancestry
asthma
Chang D et al. “A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk.” Scientific Reports 12(1):5574 (2022)
Allele G
OR 1.23
p 4.0e-8
N 6,771
Large GWAS
European
About THSD4
Predicted to enable hydrolase activity. Predicted to be an extracellular matrix structural constituent. Involved in microfibril assembly. Located in microfibril. Implicated in thoracic aortic aneurysm. [provided by Alliance of Genome Resources, Jul 2025]
View all THSD4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…