TICAM1

TIR domain containing adaptor molecule 1

Summary

This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]

Known Variants339 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs8120	19:4,816,160	A/C	regulatory region variant	benign
rs1046673	19:4,816,241	A/G	—	benign
rs199519963	19:4,816,272	G/A	—	likely benign
rs754654920	19:4,816,278	G/C	—	likely benign
rs200326236	19:4,816,283	C/T	—	uncertain significance
rs1309063391	19:4,816,287	G/C	—	likely benign
rs748477430	19:4,816,290	C/T	—	likely benign
rs756453374	19:4,816,299	G/A	—	likely benign
rs778249694	19:4,816,305	C/A	—	uncertain significance
rs891068141	19:4,816,317	C/A	—	likely benign
rs761547868	19:4,816,326	C/T	—	likely benign
rs376421303	19:4,816,340	C/T	—	uncertain significance
rs772973812	19:4,816,341	G/A	—	likely benign
rs762939077	19:4,816,344	G/A	—	likely benign
rs751074807	19:4,816,356	G/A	—	likely benign
rs536690750	19:4,816,369	G/A	—	uncertain significance
rs779499603	19:4,816,396	G/C	—	uncertain significance
rs775404991	19:4,816,416	C/A	—	likely benign
rs148396522	19:4,816,417	G/A	—	uncertain significance
rs1292695561	19:4,816,418	G/A	—	uncertain significance
rs762670581	19:4,816,423	G/C	—	uncertain significance
rs2512397316	19:4,816,450	T/C	—	uncertain significance
rs201978370	19:4,816,461	C/G	—	likely benign
rs763771528	19:4,816,462	G/C	—	uncertain significance
rs371551573	19:4,816,463	G/A	—	uncertain significance
rs779591355	19:4,816,466	G/T	—	uncertain significance
rs945545750	19:4,816,471	G/A	—	uncertain significance
rs780241594	19:4,816,487	C/T	—	uncertain significance
rs747059000	19:4,816,488	G/C	—	uncertain significance
rs749105540	19:4,816,501	G/A	—	uncertain significance
rs773993340	19:4,816,506	C/T	—	likely benign
rs759573569	19:4,816,507	G/A	—	uncertain significance
rs3177471	19:4,816,508	G/A	—	uncertain significance
rs775069081	19:4,816,515	C/T	—	likely benign
rs760042063	19:4,816,516	G/A	—	uncertain significance
rs753498364	19:4,816,524	G/A	—	likely benign
rs761523820	19:4,816,531	G/C	—	uncertain significance
rs2146167439	19:4,816,533	T/C	—	likely benign
rs201230476	19:4,816,534	G/T	—	likely benign
rs566243001	19:4,816,536	C/T	—	likely benign
rs1321096386	19:4,816,539	G/A	—	likely benign
rs751674787	19:4,816,548	G/C	—	likely benign
rs781426719	19:4,816,558	C/T	—	uncertain significance
rs545638589	19:4,816,563	A/C	—	uncertain significance
rs377447415	19:4,816,573	C/T	—	likely benign
rs2093585623	19:4,816,577	C/T	—	uncertain significance
rs2093585647	19:4,816,581	A/C	—	uncertain significance
rs772059316	19:4,816,586	G/T	—	uncertain significance
rs11466723	19:4,816,587	C/T	—	benign
rs760290741	19:4,816,588	G/C	—	uncertain significance
rs200318863	19:4,816,590	C/T	—	likely benign
rs370342886	19:4,816,593	A/C	—	likely benign
rs150224968	19:4,816,598	C/A	—	likely benign
rs561021962	19:4,816,607	T/A	—	uncertain significance
rs74359855	19:4,816,616	C/T	—	uncertain significance
rs199784356	19:4,816,627	T/G	—	benign
rs1332617784	19:4,816,635	C/T	—	likely benign
rs752768415	19:4,816,639	A/G	—	uncertain significance
rs146025102	19:4,816,651	T/C	—	uncertain significance
rs148925210	19:4,816,670	G/C	—	uncertain significance
rs2146167795	19:4,816,683	G/A	—	likely benign
rs143679494	19:4,816,688	C/T	—	conflicting classifications of pathogenicity
rs2093585998	19:4,816,694	G/T	—	uncertain significance
rs1257125762	19:4,816,701	C/T	—	likely benign
rs1427361110	19:4,816,702	G/A	—	uncertain significance
rs1467248135	19:4,816,703	C/T	—	uncertain significance
rs139939816	19:4,816,712	G/A	—	likely benign
rs2093586082	19:4,816,716	A/G	—	likely benign
rs2292151	19:4,816,719	G/A	synonymous variant	benign
rs143066432	19:4,816,721	C/T	—	uncertain significance
rs2093586143	19:4,816,727	G/A	—	uncertain significance
rs766695629	19:4,816,740	C/T	—	likely benign
rs146110283	19:4,816,742	G/A	—	uncertain significance
rs2093586206	19:4,816,749	T/C	—	likely benign
rs567288271	19:4,816,750	C/T	—	uncertain significance
rs774037288	19:4,816,751	G/C	—	uncertain significance
rs1284363590	19:4,816,758	C/G	—	uncertain significance
rs373671679	19:4,816,762	T/A	—	uncertain significance
rs377509189	19:4,816,774	A/G	—	uncertain significance
rs779772992	19:4,816,783	C/T	—	uncertain significance
rs142171170	19:4,816,790	G/T	—	uncertain significance
rs2512397922	19:4,816,812	G/A	—	likely benign
rs2093586437	19:4,816,826	T/C	—	uncertain significance
rs150740529	19:4,816,829	C/T	—	likely benign
rs772590478	19:4,816,834	A/T	—	uncertain significance
rs775931722	19:4,816,842	G/A	—	likely benign
rs2146168208	19:4,816,847	C/T	—	uncertain significance
rs543684306	19:4,816,850	C/T	—	uncertain significance
rs765491561	19:4,816,856	G/A	—	uncertain significance
rs754776028	19:4,816,862	G/T	—	uncertain significance
rs752723765	19:4,816,866	G/T	—	likely benign
rs538901003	19:4,816,881	C/G	—	likely benign
rs746263278	19:4,816,886	C/T	—	uncertain significance
rs2146168352	19:4,816,901	C/T	—	uncertain significance
rs772462289	19:4,816,902	C/G	—	likely benign
rs912548534	19:4,816,908	G/A	—	likely benign
rs1257504893	19:4,816,916	G/A	—	likely benign
rs1382708516	19:4,816,920	C/T	—	likely benign
rs199751361	19:4,816,936	C/T	—	uncertain significance
rs765583204	19:4,816,944	C/T	—	likely benign

Showing 100 of 339 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.