TLE1
TLE family member 1, transcriptional corepressor
Summary
Enables DNA-binding transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of anoikis; negative regulation of signal transduction; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs146295477 | 9:84,199,382 | T/C | — | uncertain significance |
| rs2796457 | 9:84,199,807 | C/A | — | — |
| rs202236753 | 9:84,200,531 | C/T | — | uncertain significance |
| rs2489776465 | 9:84,200,537 | A/G | — | uncertain significance |
| rs565216013 | 9:84,200,543 | C/T | — | uncertain significance |
| rs577513954 | 9:84,202,065 | G/A | — | — |
| rs766051918 | 9:84,202,611 | G/C | — | uncertain significance |
| rs150052634 | 9:84,202,637 | G/A | — | uncertain significance |
| rs2489852374 | 9:84,202,660 | T/C | — | uncertain significance |
| rs1161047980 | 9:84,205,729 | G/A | — | uncertain significance |
| rs1180834494 | 9:84,205,881 | A/C | — | uncertain significance |
| rs201140985 | 9:84,205,928 | C/T | — | uncertain significance |
| rs1829761636 | 9:84,207,948 | C/T | — | uncertain significance |
| rs778799449 | 9:84,207,977 | G/A | — | uncertain significance |
| rs776126837 | 9:84,208,026 | C/T | — | uncertain significance |
| rs61733324 | 9:84,208,039 | G/A | — | likely benign |
| rs1386746772 | 9:84,208,040 | T/A | — | uncertain significance |
| rs1829788967 | 9:84,208,189 | A/G | — | likely benign |
| rs2777777 | 9:84,213,160 | C/T | intron variant | — |
| rs815847 | 9:84,222,618 | G/A | intron variant | — |
| rs1440128955 | 9:84,225,207 | C/T | — | uncertain significance |
| rs376844498 | 9:84,226,694 | C/T | — | uncertain significance |
| rs751293312 | 9:84,226,719 | C/T | — | uncertain significance |
| rs772311750 | 9:84,226,731 | C/T | — | uncertain significance |
| rs770610621 | 9:84,226,749 | T/C | — | uncertain significance |
| rs148132074 | 9:84,226,753 | G/T | — | uncertain significance |
| rs556195256 | 9:84,226,773 | C/T | — | uncertain significance |
| rs1197695239 | 9:84,226,857 | G/A | — | uncertain significance |
| rs2489958771 | 9:84,228,399 | G/A | — | uncertain significance |
| rs754927624 | 9:84,230,928 | G/A | — | uncertain significance |
| rs763774150 | 9:84,231,036 | G/A | — | uncertain significance |
| rs151221865 | 9:84,231,042 | G/A | — | uncertain significance |
| rs374215758 | 9:84,235,427 | G/A | — | uncertain significance |
| rs1376120577 | 9:84,249,072 | C/T | — | uncertain significance |
| rs756480525 | 9:84,249,092 | G/A | — | uncertain significance |
| rs559551058 | 9:84,276,681 | A/C | — | — |
| rs181313085 | 9:84,284,224 | T/C | regulatory region variant | — |
| rs1282897383 | 9:84,300,782 | C/T | — | uncertain significance |
| rs147523347 | 9:84,302,311 | A/G | — | benign |
| rs1267718507 | 9:84,302,326 | C/A | — | uncertain significance |
| rs756549334 | 9:84,303,134 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.