TLL2
tolloid like 2
Summary
This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]
Known Variants79 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs768503540 | 10:98,127,892 | G/C | — | uncertain significance |
| rs372646234 | 10:98,127,930 | C/T | — | likely benign |
| rs191958370 | 10:98,127,931 | G/A | — | uncertain significance |
| rs764540784 | 10:98,127,960 | G/A | — | uncertain significance |
| rs1846047774 | 10:98,127,973 | C/T | — | uncertain significance |
| rs755863897 | 10:98,129,842 | C/A | — | uncertain significance |
| rs140991491 | 10:98,129,995 | G/A | — | uncertain significance |
| rs41291626 | 10:98,129,999 | G/A | — | benign |
| rs775454006 | 10:98,130,012 | A/G | — | uncertain significance |
| rs763852596 | 10:98,130,015 | T/C | — | uncertain significance |
| rs749595057 | 10:98,130,067 | C/A | — | uncertain significance |
| rs148920973 | 10:98,133,370 | T/C | — | uncertain significance |
| rs1287812731 | 10:98,133,385 | T/C | — | uncertain significance |
| rs776504923 | 10:98,133,428 | C/T | — | uncertain significance |
| rs186004686 | 10:98,133,439 | G/A | — | likely benign |
| rs368119277 | 10:98,133,461 | C/T | — | uncertain significance |
| rs747254343 | 10:98,133,490 | C/T | — | uncertain significance |
| rs748097625 | 10:98,133,496 | G/A | — | uncertain significance |
| rs770777831 | 10:98,133,503 | C/T | — | uncertain significance |
| rs10786284 | 10:98,135,505 | A/T | regulatory region variant | — |
| rs116908556 | 10:98,135,566 | A/G | regulatory region variant | — |
| rs150738442 | 10:98,136,535 | C/T | — | uncertain significance |
| rs1415303968 | 10:98,136,537 | A/C | — | uncertain significance |
| rs764937967 | 10:98,138,763 | C/T | — | uncertain significance |
| rs766275239 | 10:98,138,772 | A/G | — | uncertain significance |
| rs751468416 | 10:98,138,773 | C/G | — | uncertain significance |
| rs752320626 | 10:98,138,784 | A/G | — | uncertain significance |
| rs112143542 | 10:98,138,791 | G/C | — | benign |
| rs1181829789 | 10:98,138,823 | C/T | — | uncertain significance |
| rs370720425 | 10:98,138,835 | C/T | — | uncertain significance |
| rs142361931 | 10:98,144,368 | C/T | — | uncertain significance |
| rs1589407636 | 10:98,144,400 | T/C | — | uncertain significance |
| rs746988385 | 10:98,144,404 | C/T | — | uncertain significance |
| rs2493383295 | 10:98,144,413 | T/A | — | uncertain significance |
| rs1210296431 | 10:98,144,418 | C/T | — | uncertain significance |
| rs753228735 | 10:98,144,430 | A/C | — | uncertain significance |
| rs1377505376 | 10:98,144,437 | C/T | — | uncertain significance |
| rs746060649 | 10:98,144,452 | C/A | — | uncertain significance |
| rs61746114 | 10:98,144,491 | C/T | — | benign |
| rs374900761 | 10:98,145,855 | C/T | — | uncertain significance |
| rs141062888 | 10:98,145,865 | C/T | — | uncertain significance |
| rs749806198 | 10:98,146,726 | A/T | — | uncertain significance |
| rs750304509 | 10:98,146,745 | C/T | — | uncertain significance |
| rs754564529 | 10:98,146,769 | C/T | — | uncertain significance |
| rs746323294 | 10:98,146,790 | C/T | — | uncertain significance |
| rs2493393337 | 10:98,154,986 | C/T | — | uncertain significance |
| rs2493393418 | 10:98,155,040 | G/C | — | uncertain significance |
| rs143567200 | 10:98,155,048 | T/C | — | uncertain significance |
| rs1589410819 | 10:98,155,061 | G/A | — | uncertain significance |
| rs542313339 | 10:98,155,127 | C/T | — | uncertain significance |
| rs140598941 | 10:98,155,677 | C/T | — | benign |
| rs116160476 | 10:98,156,990 | C/T | — | benign |
| rs113406248 | 10:98,157,017 | G/A | — | uncertain significance |
| rs142713663 | 10:98,157,035 | G/A | — | uncertain significance |
| rs61741051 | 10:98,170,184 | C/G | — | benign |
| rs201561475 | 10:98,170,204 | G/A | — | uncertain significance |
| rs781651278 | 10:98,172,982 | T/C | — | uncertain significance |
| rs143633465 | 10:98,173,006 | G/A | — | uncertain significance |
| rs61743696 | 10:98,173,027 | C/T | — | likely benign |
| rs774691905 | 10:98,173,045 | G/A | — | uncertain significance |
| rs754850293 | 10:98,180,712 | C/A | — | uncertain significance |
| rs2493418725 | 10:98,180,739 | C/G | — | uncertain significance |
| rs373823527 | 10:98,180,761 | G/A | — | uncertain significance |
| rs987028272 | 10:98,180,793 | C/T | — | uncertain significance |
| rs1165347822 | 10:98,182,310 | C/G | — | uncertain significance |
| rs200756241 | 10:98,182,356 | C/T | — | uncertain significance |
| rs375633602 | 10:98,182,464 | C/T | — | uncertain significance |
| rs780965919 | 10:98,188,403 | C/A | — | uncertain significance |
| rs566307721 | 10:98,188,430 | G/A | — | uncertain significance |
| rs749406912 | 10:98,192,611 | A/G | — | uncertain significance |
| rs535050805 | 10:98,192,648 | G/A | — | uncertain significance |
| rs199935164 | 10:98,192,656 | A/T | — | uncertain significance |
| rs1239288748 | 10:98,192,683 | C/T | — | uncertain significance |
| rs2493473444 | 10:98,240,123 | G/C | — | uncertain significance |
| rs754994522 | 10:98,240,132 | G/T | — | uncertain significance |
| rs1311388005 | 10:98,240,216 | G/C | — | uncertain significance |
| rs10882807 | 10:98,268,119 | T/C | intron variant | — |
| rs1292893658 | 10:98,273,331 | C/G | — | uncertain significance |
| rs1427986533 | 10:98,273,358 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.