rs10882807
This is a intron variant variant in the TLL2 gene.
▶Research that mentions this SNP (1)
▶Genetic variants in the metzincin metallopeptidase family genes predict melanoma survivalAssociationN=1,267Yinghui Xu et al.(2018)· Molecular Carcinogenesis
A two-stage association study of 1,267 melanoma patients identified 4 independent SNPs in metzincin metallopeptidase family genes predicting melanoma-specific survival: rs10090371 in MMP16 (HR=1.73, P=9.68E-05), rs788935 in ADAMTS3 (HR=1.46, P=0.002), rs10882807 in TLL2 (HR=1.68, P=3.32E-05), and rs3918251 in MMP9 (HR=0.67, P=0.003). Combined genetic variants improved survival prediction when added to clinical variables.
About TLL2
This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]
View all TLL2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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