TNRC6B

trinucleotide repeat containing adaptor 6B

Summary

Enables RNA binding activity. Involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; and regulatory ncRNA-mediated gene silencing. Acts upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Implicated in subserous uterine fibroid and uterine fibroid. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants334 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs9623117	22:40,452,119	T/C	intron variant	—
rs58133635	22:40,471,188	C/T	intron variant	—
rs111400428	22:40,524,583	A/G	intron variant	—
rs1807579	22:40,528,220	T/C	intron variant	—
rs4586740	22:40,540,762	T/A	—	—
rs57774511	22:40,544,031	T/C	intron variant	—
rs5995825	22:40,544,337	C/G	—	—
rs146996627	22:40,552,117	A/G	—	association
rs9611280	22:40,552,119	A/G	—	benign
rs866332460	22:40,552,128	G/T	—	uncertain significance
rs1405894382	22:40,552,156	A/G	—	uncertain significance
rs1601847316	22:40,552,177	A/C	—	uncertain significance
rs4402860	22:40,554,445	A/G	—	—
rs11705370	22:40,555,993	T/A	intron variant	—
rs4820405	22:40,556,447	T/C	—	—
rs12484438	22:40,558,064	T/C	intron variant	—
rs1474667	22:40,559,156	G/A	intron variant	—
rs6001817	22:40,561,759	G/C	—	—
rs9607693	22:40,566,829	G/A	intron variant	—
rs2146376646	22:40,574,145	G/A	—	uncertain significance
rs738450	22:40,585,744	A/G	intron variant	—
rs6001831	22:40,591,258	T/C	—	—
rs6001840	22:40,604,131	A/C	intron variant	—
rs28722029	22:40,611,012	G/A	—	—
rs2146470993	22:40,642,016	T/A	—	uncertain significance
rs2146471012	22:40,642,029	C/T	—	pathogenic
rs772968885	22:40,647,197	A/C	—	likely benign
rs1325642993	22:40,647,209	G/T	—	uncertain significance
rs12484776	22:40,652,873	A/G	intron variant	—
rs12628051	22:40,654,276	T/A	—	—
rs2517980289	22:40,657,841	G/T	—	pathogenic
rs765835653	22:40,657,877	G/A	—	uncertain significance
rs2517980387	22:40,657,885	A/G	—	likely benign
rs577487172	22:40,657,886	A/G	—	likely benign
rs368015002	22:40,657,887	T/C	—	uncertain significance
rs373450317	22:40,657,923	A/T	—	uncertain significance
rs2070391663	22:40,657,935	G/A	—	uncertain significance
rs770438837	22:40,657,947	C/T	—	uncertain significance
rs2517980537	22:40,657,955	C/A	—	uncertain significance
rs760307778	22:40,657,959	C/T	—	uncertain significance
rs2517980575	22:40,657,973	C/G	—	uncertain significance
rs2517980581	22:40,657,980	T/C	—	uncertain significance
rs2517980583	22:40,657,983	C/T	—	uncertain significance
rs2517980747	22:40,658,052	C/A	—	uncertain significance
rs373838599	22:40,658,056	A/G	—	likely benign
rs376401713	22:40,658,059	G/A	—	likely benign
rs1389858414	22:40,658,067	T/A	—	uncertain significance
rs560051696	22:40,658,117	A/G	—	uncertain significance
rs1445497545	22:40,658,121	C/G	—	uncertain significance
rs527289260	22:40,658,129	G/A	—	uncertain significance
rs199636556	22:40,658,145	C/T	—	benign
rs771353369	22:40,658,146	G/A	—	likely benign
rs761493535	22:40,658,157	G/A	—	uncertain significance
rs930678025	22:40,658,169	C/A	—	uncertain significance
rs780746701	22:40,660,730	A/G	—	uncertain significance
rs769449771	22:40,660,738	T/C	—	likely benign
rs914064821	22:40,660,754	T/G	—	uncertain significance
rs1196617827	22:40,660,764	A/G	—	uncertain significance
rs1363269801	22:40,660,766	G/A	—	uncertain significance
rs374065718	22:40,660,814	G/A	—	uncertain significance
rs2517984566	22:40,660,821	A/T	—	uncertain significance
rs777315934	22:40,660,829	G/C	—	likely benign
rs182075968	22:40,660,856	A/G	—	benign
rs2070450968	22:40,660,874	A/G	—	uncertain significance
rs750813622	22:40,660,883	G/A	—	uncertain significance
rs2146498341	22:40,660,893	G/A	—	uncertain significance
rs369518020	22:40,660,990	C/G	—	uncertain significance
rs2517984979	22:40,661,011	G/A	—	likely pathogenic
rs2146498548	22:40,661,026	G/A	—	likely benign
rs186669938	22:40,661,041	A/G	—	likely benign
rs369264386	22:40,661,092	T/C	—	likely benign
rs2517985199	22:40,661,099	G/T	—	uncertain significance
rs73165082	22:40,661,112	T/C	—	conflicting classifications of pathogenicity
rs1404351609	22:40,661,114	G/A	—	uncertain significance
rs759765630	22:40,661,124	C/T	—	uncertain significance
rs78817490	22:40,661,149	T/C	—	likely benign
rs752331221	22:40,661,151	G/A	—	uncertain significance
rs2146498851	22:40,661,167	G/A	—	uncertain significance
rs1244969198	22:40,661,179	C/T	—	likely benign
rs1432454961	22:40,661,222	A/G	—	uncertain significance
rs2517985545	22:40,661,244	G/A	—	uncertain significance
rs373583811	22:40,661,261	T/G	—	likely benign
rs2070459385	22:40,661,262	C/G	—	uncertain significance
rs2070459571	22:40,661,266	G/A	—	likely benign
rs375322900	22:40,661,292	C/A	—	uncertain significance
rs200804069	22:40,661,301	A/T	—	likely benign
rs2146499114	22:40,661,324	C/T	—	pathogenic
rs558311471	22:40,661,337	A/G	—	likely benign
rs2517985715	22:40,661,345	G/A	—	uncertain significance
rs2517985916	22:40,661,423	G/A	—	uncertain significance
rs747365401	22:40,661,459	G/T	—	likely benign
rs1442058429	22:40,661,464	T/G	—	likely benign
rs201621003	22:40,661,483	C/T	—	pathogenic
rs1368430664	22:40,661,501	G/C	—	uncertain significance
rs201057205	22:40,661,502	G/T	—	conflicting classifications of pathogenicity
rs781727284	22:40,661,523	G/A	—	uncertain significance
rs1238488586	22:40,661,541	C/G	—	uncertain significance
rs2146499470	22:40,661,543	G/A	—	uncertain significance
rs376017741	22:40,661,545	C/G	—	likely benign
rs757174572	22:40,661,559	A/G	—	uncertain significance

Showing 100 of 334 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.