TRABD2B
TraB domain containing 2B
Summary
Enables Wnt-protein binding activity and metalloendopeptidase activity. Involved in several processes, including negative regulation of Wnt signaling pathway; positive regulation of protein oxidation; and positive regulation of protein-containing complex assembly. Located in nucleoplasm; organelle membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants29 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1048824037 | 1:48,240,923 | C/T | — | uncertain significance |
| rs1022051941 | 1:48,240,948 | G/T | — | uncertain significance |
| rs569339407 | 1:48,240,993 | C/T | — | uncertain significance |
| rs1031097780 | 1:48,241,029 | C/T | — | uncertain significance |
| rs1235986922 | 1:48,241,049 | G/A | — | uncertain significance |
| rs1644432622 | 1:48,241,100 | T/C | — | likely benign |
| rs1198272847 | 1:48,244,130 | G/T | — | uncertain significance |
| rs748551785 | 1:48,244,193 | C/T | — | uncertain significance |
| rs6588505 | 1:48,254,782 | C/T | intron variant | — |
| rs1644720339 | 1:48,260,261 | C/T | — | uncertain significance |
| rs1236008749 | 1:48,260,396 | C/T | — | uncertain significance |
| rs147317864 | 1:48,267,174 | C/A | — | uncertain significance |
| rs6662938 | 1:48,278,008 | T/C | intron variant | — |
| rs75323670 | 1:48,311,720 | C/G | intron variant | — |
| rs946836 | 1:48,321,221 | C/T | intron variant | — |
| rs10493130 | 1:48,341,005 | G/C | — | — |
| rs11211631 | 1:48,383,741 | A/T | — | — |
| rs12080929 | 1:48,436,148 | T/C | intron variant | — |
| rs987993543 | 1:48,459,876 | C/T | — | uncertain significance |
| rs2522195316 | 1:48,459,939 | G/A | — | uncertain significance |
| rs750996564 | 1:48,459,948 | C/T | — | uncertain significance |
| rs757993011 | 1:48,459,986 | T/C | — | uncertain significance |
| rs188128120 | 1:48,460,057 | G/A | — | likely benign |
| rs1028304175 | 1:48,460,088 | G/A | — | uncertain significance |
| rs758885728 | 1:48,460,130 | C/T | — | likely benign |
| rs1646062548 | 1:48,460,223 | G/A | — | uncertain significance |
| rs926281488 | 1:48,460,241 | G/A | — | uncertain significance |
| rs926498175 | 1:48,462,418 | G/A | — | uncertain significance |
| rs1646099209 | 1:48,462,452 | C/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.