rs10493130

This variant is located in the TRABD2B gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

heel bone mineral density

Morris JA et al. “An atlas of genetic influences on osteoporosis in humans and mice.” Nature Genetics 51(2):258-266 (2019)

Allele G

OR 0.01

p 2.0e-9

N 426,824

Large GWAS

European

Liu L et al. “Twelve New Genomic Loci Associated With Bone Mineral Density.” Frontiers in Endocrinology 11:243 (2020)

Allele G

OR 0.01

p 3.0e-8

N 426,824

Large GWAS

About TRABD2B

Enables Wnt-protein binding activity and metalloendopeptidase activity. Involved in several processes, including negative regulation of Wnt signaling pathway; positive regulation of protein oxidation; and positive regulation of protein-containing complex assembly. Located in nucleoplasm; organelle membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

View all TRABD2B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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