TRAF3IP2

TRAF3 interacting protein 2

Summary

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

Known Variants226 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1432489906:111,880,614G/C—likely benign
rs25360871426:111,880,620C/A—likely benign
rs15624156696:111,880,625G/A—uncertain significance
rs17953525106:111,880,626A/G—likely benign
rs7605148576:111,880,629G/C—likely benign
rs7699584176:111,880,632G/T—likely benign
rs14675395166:111,880,645C/T—uncertain significance
rs25360874486:111,880,670C/T—uncertain significance
rs1860978016:111,880,692G/A—benign
rs25360876476:111,880,709G/A—uncertain significance
rs2020900666:111,880,723T/C—benign
rs3975184856:111,880,726G/Amissense variantpathogenic
rs21283680856:111,880,731C/T—likely benign
rs21283680876:111,880,732T/C—uncertain significance
rs25360877656:111,880,738C/G—uncertain significance
rs21283680986:111,880,742T/C—uncertain significance
rs15624158086:111,880,754C/A—uncertain significance
rs2020206406:111,880,760G/T—likely benign
rs2018554986:111,884,154C/G—likely benign
rs7645402856:111,884,189C/T—likely benign
rs9051691516:111,884,195G/A—likely benign
rs10533400066:111,884,212T/C—uncertain significance
rs13504164426:111,884,255A/T—uncertain significance
rs25360981066:111,884,257A/G—likely benign
rs7647367406:111,887,651C/T—uncertain significance
rs17956371536:111,887,652G/A—pathogenic
rs14198474966:111,887,666G/A—uncertain significance
rs1414598206:111,887,683A/C—uncertain significance
rs1495045436:111,887,688C/T—uncertain significance
rs1441669466:111,887,689G/A—likely benign
rs3677844206:111,887,699G/A—uncertain significance
rs1118153066:111,887,706C/T—uncertain significance
rs7558638416:111,887,707G/A—likely benign
rs12378127086:111,887,715C/T—uncertain significance
rs1504364556:111,887,716G/A—likely benign
rs17956411266:111,887,727A/T—uncertain significance
rs7757762626:111,887,745C/T—uncertain significance
rs3713821526:111,887,746G/A—likely benign
rs17956422056:111,887,753A/G—uncertain significance
rs2002132706:111,887,758G/A—benign
rs17956443676:111,887,772G/C—likely benign
rs21283714566:111,887,776G/C—likely benign
rs7773104036:111,887,778G/C—likely benign
rs13528320566:111,888,840C/T—uncertain significance
rs2002468826:111,888,841G/A—uncertain significance
rs2009912856:111,888,842C/T—likely benign
rs11979324946:111,888,858A/G—uncertain significance
rs21283720586:111,888,903A/C—likely benign
rs21283720706:111,888,909G/C—likely benign
rs7783696316:111,894,083G/A—likely benign
rs15832231716:111,894,102G/T—pathogenic
rs5710963746:111,894,113A/G—likely benign
rs8948602576:111,894,122C/T—likely benign
rs9329347556:111,894,134G/A—likely benign
rs12538646196:111,894,139T/C—uncertain significance
rs14445613146:111,894,152A/G—likely benign
rs617576476:111,894,155T/A—benign
rs7616444256:111,894,164C/T—likely benign
rs7651124696:111,894,167A/G—likely benign
rs21283743776:111,894,202T/C—likely benign
rs5350976806:111,895,598T/G——
rs121927056:111,896,777C/T—benign
rs3731289116:111,896,796A/G—benign
rs13884936206:111,896,834C/G—likely benign
rs13218990756:111,896,844A/G—likely pathogenic
rs3758006446:111,896,845C/G—likely pathogenic
rs7675963616:111,896,846G/A—uncertain significance
rs7642279466:111,896,854T/G—uncertain significance
rs7539545836:111,896,862A/G—likely benign
rs1397678406:111,896,863T/C—likely benign
rs21283757126:111,896,921C/T—uncertain significance
rs17959629786:111,896,926G/T—uncertain significance
rs3700112316:111,896,928C/T—likely benign
rs9040373716:111,896,958T/C—likely benign
rs7733163506:111,896,965C/T—uncertain significance
rs7625919126:111,896,976C/T—likely benign
rs1438657506:111,896,983G/A—uncertain significance
rs7609167076:111,896,984G/C—uncertain significance
rs1486198496:111,896,989C/T—uncertain significance
rs21283757816:111,896,998T/C—uncertain significance
rs7588884486:111,897,015T/C—likely benign
rs17959685366:111,897,023C/T—uncertain significance
rs21283758076:111,897,027A/G—uncertain significance
rs17959688966:111,897,028G/C—likely benign
rs25361520876:111,901,384G/T—likely benign
rs7592691536:111,901,393T/C—likely benign
rs15624270786:111,901,397T/C—uncertain significance
rs12394361216:111,901,401G/C—uncertain significance
rs2007036496:111,901,402G/A—benign
rs7618226836:111,901,414C/T—likely benign
rs17961111466:111,901,416C/G—uncertain significance
rs5598745986:111,901,418G/A—uncertain significance
rs5620581806:111,901,429G/A—likely benign
rs12791204036:111,901,433C/G—uncertain significance
rs3692106806:111,901,438T/C—likely benign
rs7519061006:111,901,440C/T—uncertain significance
rs1120361276:111,901,441G/A—likely benign
rs10437306:111,901,453G/T—likely benign
rs5422800806:111,901,463G/A—uncertain significance
rs1462263656:111,901,465G/T—benign

Showing 100 of 226 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.