TRDMT1

tRNA aspartic acid methyltransferase 1

Summary

This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]

Known Variants32 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1090488710:17,188,641T/Cdownstream gene variant
rs77728592310:17,191,080C/Guncertain significance
rs75606516410:17,191,110G/Auncertain significance
rs77231920210:17,191,113G/Cuncertain significance
rs249230069710:17,191,124A/Guncertain significance
rs227373610:17,195,428G/Cintron variant
rs13902016710:17,195,569G/Auncertain significance
rs121275803310:17,196,690C/Tlikely benign
rs127082781110:17,199,501A/Guncertain significance
rs14240300210:17,199,649A/Cbenign
rs147628275110:17,199,753C/Guncertain significance
rs90587331110:17,199,755G/Auncertain significance
rs138477835710:17,199,757T/Auncertain significance
rs20193618010:17,199,773T/Cuncertain significance
rs11549336010:17,199,780G/Abenign
rs37071535610:17,201,228G/Tuncertain significance
rs37642840710:17,202,309T/Cuncertain significance
rs37078895410:17,202,354T/Cuncertain significance
rs92433787810:17,203,519A/Cuncertain significance
rs14307458310:17,204,201G/Auncertain significance
rs184046032710:17,204,210T/Cuncertain significance
rs37238710110:17,204,228C/Tuncertain significance
rs20000648310:17,204,248A/Tintron variant
rs75505212610:17,210,861G/Auncertain significance
rs77519242210:17,210,904C/Guncertain significance
rs20198077210:17,216,554A/Guncertain significance
rs76732845710:17,216,572T/Guncertain significance
rs145752089710:17,216,606T/Cuncertain significance
rs37346760910:17,216,648G/Cuncertain significance
rs1278084510:17,223,244A/Gintron variant
rs188539610:17,243,351C/G
rs136781679310:17,243,573T/Cuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.