rs12780845

This is a intron variant variant in the TRDMT1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

homocysteine measurement

van Meurs JB et al. “Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.” The American Journal of Clinical Nutrition 98(3):668-76 (2013)

Allele A

OR 0.05

p 8.0e-10

N 44,147

Large GWAS

European

About TRDMT1

This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]

View all TRDMT1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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