TRIM25
tripartite motif containing 25
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 ligase and is involved in multiple cellular processes, including regulation of antiviral innate immunity. [provided by RefSeq, Sep 2021]
Known Variants39 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1368290262 | 17:54,969,173 | G/A | — | uncertain significance |
| rs763140638 | 17:54,969,209 | T/C | — | uncertain significance |
| rs61738274 | 17:54,969,229 | C/T | — | benign |
| rs200806739 | 17:54,969,287 | G/C | — | uncertain significance |
| rs113318936 | 17:54,969,304 | G/A | — | likely benign |
| rs764516557 | 17:54,969,320 | T/C | — | uncertain significance |
| rs749116784 | 17:54,969,363 | C/T | — | uncertain significance |
| rs1412796147 | 17:54,969,474 | T/C | — | uncertain significance |
| rs2509367721 | 17:54,969,493 | G/T | — | uncertain significance |
| rs1567837518 | 17:54,969,546 | C/T | — | uncertain significance |
| rs201869398 | 17:54,969,585 | T/C | — | likely benign |
| rs205499 | 17:54,972,401 | G/A | downstream gene variant | — |
| rs148468374 | 17:54,972,783 | G/T | — | uncertain significance |
| rs1423926714 | 17:54,972,797 | C/A | — | uncertain significance |
| rs138945765 | 17:54,973,661 | A/G | downstream gene variant | — |
| rs2525996 | 17:54,976,304 | C/G | intron variant | — |
| rs118047053 | 17:54,976,502 | G/A | — | uncertain significance |
| rs148989739 | 17:54,976,512 | T/C | — | uncertain significance |
| rs139560285 | 17:54,977,570 | G/A | intron variant | — |
| rs205498 | 17:54,978,794 | G/A | missense variant | — |
| rs767391521 | 17:54,978,872 | T/C | — | uncertain significance |
| rs1392800375 | 17:54,981,650 | C/T | — | uncertain significance |
| rs138531008 | 17:54,981,783 | C/T | — | uncertain significance |
| rs759631465 | 17:54,981,831 | C/T | — | likely benign |
| rs764695048 | 17:54,985,831 | G/A | — | uncertain significance |
| rs762502765 | 17:54,985,834 | C/T | — | uncertain significance |
| rs1319666337 | 17:54,985,849 | T/C | — | uncertain significance |
| rs7213666 | 17:54,985,874 | C/T | — | benign |
| rs759699144 | 17:54,985,896 | A/T | — | uncertain significance |
| rs138027563 | 17:54,990,784 | G/A | — | likely benign |
| rs763430514 | 17:54,990,788 | G/A | — | uncertain significance |
| rs61731983 | 17:54,990,797 | T/C | — | benign |
| rs2509383328 | 17:54,990,821 | G/C | — | uncertain significance |
| rs2509383483 | 17:54,990,899 | C/G | — | uncertain significance |
| rs920084993 | 17:54,990,910 | G/A | — | uncertain significance |
| rs759843788 | 17:54,991,063 | G/T | — | uncertain significance |
| rs549667830 | 17:54,991,070 | C/T | — | uncertain significance |
| rs754704206 | 17:54,991,103 | G/A | — | uncertain significance |
| rs762390277 | 17:54,991,208 | A/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.