rs139560285

This is a intron variant variant in the TRIM25 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Park JM et al. “Genome-wide approach to study gene-nutrient intake interactions in type 2 diabetes mellitus in a large Korean cohort.” Frontiers in Nutrition 12:1538813 (2025)

Allele A

OR 2.02

p 4.0e-8

N 6,000

Large GWAS

East Asian

About TRIM25

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 ligase and is involved in multiple cellular processes, including regulation of antiviral innate immunity. [provided by RefSeq, Sep 2021]

View all TRIM25 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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