TRIM65
tripartite motif containing 65
Summary
Enables ubiquitin protein ligase activity. Involved in negative regulation of inflammatory response; positive regulation of metabolic process; and protein polyubiquitination. Located in cytosol and nucleoplasm. Is active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants57 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs142186653 | 17:73,879,851 | A/C | downstream gene variant | — |
| rs35392904 | 17:73,883,918 | T/C | downstream gene variant | — |
| rs1443895105 | 17:73,886,882 | G/A | — | likely benign |
| rs374109368 | 17:73,886,937 | C/G | — | uncertain significance |
| rs137974930 | 17:73,887,009 | G/T | — | uncertain significance |
| rs1429560056 | 17:73,887,071 | C/T | — | uncertain significance |
| rs145909647 | 17:73,887,135 | C/G | — | uncertain significance |
| rs2546027152 | 17:73,887,149 | G/A | — | uncertain significance |
| rs200457465 | 17:73,887,152 | C/A | — | uncertain significance |
| rs369294498 | 17:73,887,161 | C/T | — | uncertain significance |
| rs762684128 | 17:73,887,219 | C/T | — | uncertain significance |
| rs750895177 | 17:73,887,245 | G/A | — | uncertain significance |
| rs374478460 | 17:73,887,248 | C/T | — | uncertain significance |
| rs202175254 | 17:73,887,270 | C/T | — | uncertain significance |
| rs2065261618 | 17:73,887,327 | C/T | — | uncertain significance |
| rs368015889 | 17:73,887,368 | T/C | — | uncertain significance |
| rs184759429 | 17:73,887,371 | C/A | — | uncertain significance |
| rs144407004 | 17:73,887,372 | G/A | — | uncertain significance |
| rs200651117 | 17:73,887,389 | C/T | — | uncertain significance |
| rs758468327 | 17:73,887,914 | A/C | — | uncertain significance |
| rs2065271984 | 17:73,887,941 | G/A | — | uncertain significance |
| rs762217267 | 17:73,888,139 | C/T | — | uncertain significance |
| rs765026671 | 17:73,888,151 | A/T | — | uncertain significance |
| rs867386555 | 17:73,888,160 | C/T | — | uncertain significance |
| rs751544594 | 17:73,888,178 | T/G | — | uncertain significance |
| rs551753319 | 17:73,888,223 | G/T | — | likely benign |
| rs535797443 | 17:73,888,250 | T/C | — | uncertain significance |
| rs148051812 | 17:73,888,407 | G/A | — | uncertain significance |
| rs368813627 | 17:73,888,436 | C/T | — | uncertain significance |
| rs776512559 | 17:73,888,446 | C/T | — | uncertain significance |
| rs765026510 | 17:73,888,451 | C/T | — | likely benign |
| rs768371299 | 17:73,888,466 | G/A | — | likely benign |
| rs145657229 | 17:73,888,478 | G/A | — | uncertain significance |
| rs147573058 | 17:73,888,486 | G/A | — | likely benign |
| rs767818513 | 17:73,888,517 | T/G | — | uncertain significance |
| rs779705680 | 17:73,888,559 | G/A | — | uncertain significance |
| rs3744028 | 17:73,888,672 | T/G | — | — |
| rs3744027 | 17:73,888,743 | G/A | regulatory region variant | — |
| rs371626754 | 17:73,888,858 | C/T | — | uncertain significance |
| rs140315342 | 17:73,888,880 | C/T | — | uncertain significance |
| rs1302179624 | 17:73,888,892 | C/T | — | uncertain significance |
| rs9901840 | 17:73,889,412 | T/A | upstream gene variant | — |
| rs2065349174 | 17:73,892,619 | G/A | — | uncertain significance |
| rs746808889 | 17:73,892,684 | C/G | — | uncertain significance |
| rs1049106187 | 17:73,892,699 | C/T | — | uncertain significance |
| rs535596424 | 17:73,892,712 | C/T | — | uncertain significance |
| rs1178503572 | 17:73,892,725 | G/C | — | uncertain significance |
| rs770946179 | 17:73,892,730 | G/A | — | uncertain significance |
| rs951870593 | 17:73,892,750 | T/G | — | uncertain significance |
| rs1256281792 | 17:73,892,831 | T/A | — | uncertain significance |
| rs1415543840 | 17:73,892,867 | C/G | — | uncertain significance |
| rs749951628 | 17:73,892,909 | C/T | — | uncertain significance |
| rs749450735 | 17:73,892,964 | A/G | — | uncertain significance |
| rs374692828 | 17:73,892,982 | C/T | — | uncertain significance |
| rs372775089 | 17:73,892,987 | G/C | — | uncertain significance |
| rs991753133 | 17:73,892,988 | T/C | — | uncertain significance |
| rs766262142 | 17:73,893,008 | T/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.