rs3744028

This variant is located in the TRIM65 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

brain attribute

Fornage M. et al. “Genome‐wide association studies of cerebral white matter lesion burden” Annals of Neurology (2011)
Allele C
OR —
p 4.0e-15
N 9,361
Large GWAS
European
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Research that mentions this SNP (1)

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Genome‐wide association studies of cerebral white matter lesion burden
Meta-analysisN=12,385Fornage M. et al.(2011)· Annals of Neurology

Genome-wide meta-analysis of 9,361 Europeans identified six genome-wide significant SNPs on chromosome 17q25 associated with white matter hyperintensity (WMH) burden. The most significant SNP, rs3744028 (P = 4.0×10⁻⁹ discovery, P = 1.3×10⁻⁷ replication, P = 4.0×10⁻¹⁵ combined), and rs1055129 were replicated in 3,024 additional individuals. Risk alleles increased WMH burden by 4-8% of mean burden.

Traits studied:Cerebral white matter lesionsWhite matter hyperintensities (WMH) burden
PubMedDOIMetascience Observatory

About TRIM65

Enables ubiquitin protein ligase activity. Involved in negative regulation of inflammatory response; positive regulation of metabolic process; and protein polyubiquitination. Located in cytosol and nucleoplasm. Is active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

View all TRIM65 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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