TRPM8
transient receptor potential cation channel subfamily M member 8
Summary
Predicted to enable ligand-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including intracellular calcium ion homeostasis; response to cold; and thermoception. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants84 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1985366 | 2:234,824,559 | T/A | — | — |
| rs10166942 | 2:234,825,093 | T/A | — | — |
| rs572770153 | 2:234,825,454 | C/T | — | — |
| rs1003540 | 2:234,825,884 | A/G | upstream gene variant | — |
| rs6741751 | 2:234,827,661 | G/A | intron variant | — |
| rs11563062 | 2:234,829,239 | G/A | intron variant | — |
| rs185330631 | 2:234,830,018 | G/A | intron variant | — |
| rs149800225 | 2:234,835,194 | G/A | — | likely benign |
| rs776737159 | 2:234,835,196 | C/A | — | uncertain significance |
| rs200473098 | 2:234,835,247 | G/A | — | uncertain significance |
| rs1368694089 | 2:234,835,253 | T/A | — | uncertain significance |
| rs199755852 | 2:234,835,264 | G/A | — | uncertain significance |
| rs767031540 | 2:234,839,317 | T/C | — | uncertain significance |
| rs772636169 | 2:234,839,321 | G/T | — | likely benign |
| rs1280265033 | 2:234,845,998 | G/C | — | uncertain significance |
| rs149029668 | 2:234,846,106 | G/A | — | uncertain significance |
| rs758120903 | 2:234,846,123 | T/G | — | uncertain significance |
| rs138133683 | 2:234,847,674 | A/C | — | uncertain significance |
| rs200821010 | 2:234,847,775 | T/C | — | uncertain significance |
| rs201611229 | 2:234,847,787 | T/C | — | uncertain significance |
| rs190304256 | 2:234,847,790 | G/A | — | uncertain significance |
| rs35124867 | 2:234,851,265 | A/G | — | uncertain significance |
| rs765214802 | 2:234,851,268 | T/C | — | uncertain significance |
| rs769781772 | 2:234,851,348 | A/C | — | uncertain significance |
| rs28901630 | 2:234,851,371 | C/G | — | benign |
| rs12472151 | 2:234,852,692 | G/A | downstream gene variant | — |
| rs13004520 | 2:234,854,540 | G/C | — | benign |
| rs11562975 | 2:234,854,550 | G/A | synonymous variant | — |
| rs745586338 | 2:234,854,587 | G/A | — | uncertain significance |
| rs140382067 | 2:234,854,620 | G/A | — | uncertain significance |
| rs200066478 | 2:234,854,632 | C/T | — | uncertain significance |
| rs200708894 | 2:234,858,656 | G/A | — | uncertain significance |
| rs145069600 | 2:234,858,716 | G/C | — | uncertain significance |
| rs201962335 | 2:234,858,729 | G/A | — | uncertain significance |
| rs140502895 | 2:234,858,771 | C/T | — | uncertain significance |
| rs1418038362 | 2:234,858,777 | G/A | — | uncertain significance |
| rs145140312 | 2:234,862,650 | C/T | — | benign |
| rs1559527331 | 2:234,863,803 | A/G | — | uncertain significance |
| rs140612583 | 2:234,863,848 | T/C | — | uncertain significance |
| rs200356940 | 2:234,863,882 | C/T | — | likely benign |
| rs182733234 | 2:234,863,883 | C/A | — | uncertain significance |
| rs139003916 | 2:234,863,904 | A/C | — | benign |
| rs199815566 | 2:234,863,917 | T/A | coding sequence variant | — |
| rs375873836 | 2:234,869,412 | C/T | — | likely benign |
| rs28902173 | 2:234,869,442 | T/C | — | benign |
| rs76512385 | 2:234,869,523 | C/T | — | uncertain significance |
| rs1383554900 | 2:234,869,537 | A/G | — | uncertain significance |
| rs375855782 | 2:234,869,555 | C/A | — | uncertain significance |
| rs201941621 | 2:234,869,652 | G/A | — | uncertain significance |
| rs758641743 | 2:234,869,672 | G/C | — | uncertain significance |
| rs200707338 | 2:234,869,684 | C/T | — | uncertain significance |
| rs11563130 | 2:234,869,692 | G/A | — | benign |
| rs112967138 | 2:234,870,502 | G/A | intron variant | — |
| rs572730173 | 2:234,871,783 | A/G | — | — |
| rs2469839290 | 2:234,873,281 | T/C | — | uncertain significance |
| rs7562378 | 2:234,874,783 | T/C | intron variant | — |
| rs200565353 | 2:234,875,247 | G/A | — | likely benign |
| rs2469854680 | 2:234,875,292 | G/C | — | uncertain significance |
| rs2469855289 | 2:234,875,387 | G/T | — | uncertain significance |
| rs774641388 | 2:234,878,386 | G/C | — | uncertain significance |
| rs766440724 | 2:234,878,419 | A/G | — | uncertain significance |
| rs764238693 | 2:234,878,909 | A/G | — | uncertain significance |
| rs17862932 | 2:234,878,910 | C/T | missense variant | — |
| rs972578403 | 2:234,878,951 | A/G | — | uncertain significance |
| rs557265313 | 2:234,887,544 | G/T | — | — |
| rs1166064650 | 2:234,888,844 | G/A | — | uncertain significance |
| rs779536818 | 2:234,888,847 | G/A | — | uncertain significance |
| rs200970660 | 2:234,888,851 | A/G | — | uncertain significance |
| rs200017552 | 2:234,888,884 | C/T | — | uncertain significance |
| rs560346678 | 2:234,888,898 | T/C | — | uncertain significance |
| rs769614714 | 2:234,888,916 | G/A | — | uncertain significance |
| rs28902201 | 2:234,890,432 | A/G | — | benign |
| rs1225841707 | 2:234,890,445 | G/T | — | uncertain significance |
| rs149328116 | 2:234,891,850 | G/A | missense variant | — |
| rs145230970 | 2:234,891,855 | C/A | — | benign |
| rs139760142 | 2:234,894,385 | C/A | — | uncertain significance |
| rs539858813 | 2:234,894,430 | T/C | — | uncertain significance |
| rs2469994021 | 2:234,894,473 | A/C | — | uncertain significance |
| rs1240326192 | 2:234,905,089 | A/G | — | uncertain significance |
| rs2470065273 | 2:234,905,103 | G/T | — | uncertain significance |
| rs201836188 | 2:234,915,578 | C/T | — | uncertain significance |
| rs28953469 | 2:234,918,776 | G/A | — | — |
| rs762865598 | 2:234,923,237 | T/C | — | uncertain significance |
| rs1987842 | 2:234,928,517 | G/A | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.