rs10166942
This variant is located in the TRPM8 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
migraine disorder
Hautakangas H et al. “Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.” Nature Genetics 54(2):152-160 (2022)
Allele T
OR 1.10
p 9.0e-51
N 873,341
Large GWAS
European
Choquet H et al. “New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis.” Communications Biology 4(1):864 (2021)
Allele T
OR 0.91
p 2.0e-39
N 889,018
Meta-analysisLarge GWAS
European
Chasman DI et al. “Genome-wide association study reveals three susceptibility loci for common migraine in the general population.” Nature Genetics 43(7):695-8 (2011)
Allele T
OR 1.18
p 6.0e-12
N 23,230
Large GWAS
European
About TRPM8
Predicted to enable ligand-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including intracellular calcium ion homeostasis; response to cold; and thermoception. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all TRPM8 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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