TSKU
tsukushi, small leucine rich proteoglycan
Summary
Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in several processes, including cholesterol efflux; cholesterol homeostasis; and nervous system development. Predicted to act upstream of or within several processes, including ciliary body morphogenesis; negative regulation of Wnt signaling pathway; and telencephalon development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants37 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs75694075 | 11:76,494,760 | T/C | regulatory region variant | — |
| rs1440980 | 11:76,495,076 | C/T | regulatory region variant | — |
| rs1837680 | 11:76,501,451 | G/A | upstream gene variant | — |
| rs10899282 | 11:76,504,698 | G/A | regulatory region variant | — |
| rs10899283 | 11:76,505,202 | C/G | — | — |
| rs148573319 | 11:76,506,690 | C/T | — | benign |
| rs202220235 | 11:76,506,691 | G/C | — | uncertain significance |
| rs140232134 | 11:76,506,811 | A/T | — | uncertain significance |
| rs779955198 | 11:76,506,818 | C/T | — | uncertain significance |
| rs761996929 | 11:76,506,902 | C/G | — | uncertain significance |
| rs1590821303 | 11:76,506,968 | C/A | — | uncertain significance |
| rs760910965 | 11:76,506,983 | G/A | — | uncertain significance |
| rs150218579 | 11:76,506,995 | C/T | — | uncertain significance |
| rs142984672 | 11:76,507,024 | G/A | — | uncertain significance |
| rs200202157 | 11:76,507,063 | G/A | — | uncertain significance |
| rs143993207 | 11:76,507,090 | C/T | — | uncertain significance |
| rs200873251 | 11:76,507,118 | C/T | — | uncertain significance |
| rs200400905 | 11:76,507,142 | A/C | — | uncertain significance |
| rs148661218 | 11:76,507,144 | G/T | — | likely benign |
| rs142190066 | 11:76,507,157 | A/C | — | uncertain significance |
| rs1214798445 | 11:76,507,172 | G/A | — | uncertain significance |
| rs749986558 | 11:76,507,190 | C/T | — | uncertain significance |
| rs778328730 | 11:76,507,208 | C/T | — | uncertain significance |
| rs1343652878 | 11:76,507,255 | G/A | — | uncertain significance |
| rs769827519 | 11:76,507,331 | C/A | — | uncertain significance |
| rs768003667 | 11:76,507,390 | G/C | — | likely benign |
| rs201426204 | 11:76,507,397 | C/T | — | uncertain significance |
| rs149185997 | 11:76,507,411 | C/T | — | uncertain significance |
| rs367560521 | 11:76,507,520 | C/T | — | uncertain significance |
| rs776667905 | 11:76,507,531 | C/G | — | uncertain significance |
| rs537110468 | 11:76,507,558 | C/T | — | uncertain significance |
| rs757427379 | 11:76,507,618 | G/C | — | uncertain significance |
| rs890129397 | 11:76,507,643 | G/C | — | uncertain significance |
| rs771653839 | 11:76,507,663 | G/T | — | uncertain significance |
| rs543814340 | 11:76,507,686 | C/T | — | likely benign |
| rs200686423 | 11:76,507,687 | C/T | — | uncertain significance |
| rs950600348 | 11:76,507,693 | T/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.