TYRO3
TYRO3 protein tyrosine kinase
Summary
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]
Known Variants46 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs148972694 | 15:41,853,402 | G/C | — | uncertain significance |
| rs942112509 | 15:41,853,429 | G/T | — | uncertain significance |
| rs199972928 | 15:41,853,484 | A/G | — | uncertain significance |
| rs753643768 | 15:41,853,737 | C/A | — | uncertain significance |
| rs56363203 | 15:41,854,885 | C/T | — | benign |
| rs1023193 | 15:41,855,736 | T/G | intron variant | — |
| rs138227584 | 15:41,856,401 | G/A | — | uncertain significance |
| rs760643930 | 15:41,856,439 | C/T | — | uncertain significance |
| rs779051778 | 15:41,857,282 | T/G | — | uncertain significance |
| rs139608785 | 15:41,859,604 | C/T | — | uncertain significance |
| rs144221692 | 15:41,859,715 | C/T | — | uncertain significance |
| rs2550240990 | 15:41,860,545 | A/T | — | uncertain significance |
| rs2289743 | 15:41,860,698 | C/G | regulatory region variant | — |
| rs199712738 | 15:41,861,163 | G/A | — | uncertain significance |
| rs139291400 | 15:41,861,214 | C/T | — | uncertain significance |
| rs2550241791 | 15:41,862,234 | G/T | — | uncertain significance |
| rs745614743 | 15:41,862,261 | T/C | — | uncertain significance |
| rs2550241826 | 15:41,862,302 | G/A | — | uncertain significance |
| rs55698899 | 15:41,862,346 | G/A | — | benign |
| rs755999280 | 15:41,862,524 | G/A | — | uncertain significance |
| rs142874537 | 15:41,862,822 | G/A | — | uncertain significance |
| rs1158125835 | 15:41,862,823 | A/G | — | uncertain significance |
| rs2055783606 | 15:41,862,852 | C/T | — | uncertain significance |
| rs755401207 | 15:41,862,882 | C/G | — | uncertain significance |
| rs781746512 | 15:41,862,883 | G/A | — | uncertain significance |
| rs751069987 | 15:41,863,284 | C/T | — | uncertain significance |
| rs774870018 | 15:41,864,742 | C/T | — | uncertain significance |
| rs2550243413 | 15:41,865,303 | A/T | — | uncertain significance |
| rs62001448 | 15:41,865,525 | T/G | — | benign |
| rs116540200 | 15:41,865,543 | G/A | — | benign |
| rs1179976971 | 15:41,865,552 | C/T | — | uncertain significance |
| rs377334532 | 15:41,865,579 | C/T | — | uncertain significance |
| rs2550243581 | 15:41,865,606 | G/A | — | uncertain significance |
| rs2550243769 | 15:41,865,903 | G/C | — | uncertain significance |
| rs148896634 | 15:41,865,913 | C/T | — | uncertain significance |
| rs755886473 | 15:41,865,950 | A/T | — | uncertain significance |
| rs372061850 | 15:41,865,995 | C/T | — | uncertain significance |
| rs2550243834 | 15:41,865,999 | G/C | — | uncertain significance |
| rs3784283 | 15:41,867,782 | A/T | intron variant | — |
| rs200695279 | 15:41,870,227 | G/A | — | uncertain significance |
| rs1042057 | 15:41,870,245 | C/T | — | benign |
| rs61553785 | 15:41,870,246 | G/T | — | benign |
| rs745886196 | 15:41,870,259 | G/C | — | uncertain significance |
| rs775751001 | 15:41,870,274 | G/A | — | uncertain significance |
| rs147314538 | 15:41,870,326 | G/A | — | uncertain significance |
| rs747037135 | 15:41,870,430 | C/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.