Trait
SNPs associated with Metabolic syndrome
701 genetic variants across 76 genes have been associated with Metabolic syndrome in published research. Key genes include ABCA1, ABCG8, ABO.
Associated variants701 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs9939609 | FTO | Increased metabolic syndrome risk | Meta-analysis |
| rs1799883 | FABP2 | Increased metabolic syndrome risk | Meta-analysis |
| rs964184 | APOA5 | GWAS association (p=7.0e-167) | Major Consortium Study |
| rs247617 | — | GWAS association (p=2.0e-166) | Major Consortium Study |
| rs3844510 | — | GWAS association (p=1.0e-138) | Major Consortium Study |
| rs2075290 | ZPR1 | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs72836561 | — | GWAS association (p=5.0e-43) | Major Consortium Study |
| rs2980888 | — | GWAS association (p=4.0e-42) | Major Consortium Study |
| rs116843064 | ANGPTL4 | GWAS association (p=1.0e-37) | Major Consortium Study |
| rs2281721 | GALNT2 | GWAS association (p=1.0e-34) | Major Consortium Study |
| rs673548 | APOB | GWAS association (p=2.0e-32) | Major Consortium Study |
| rs483082 | APOC1 | GWAS association (p=2.0e-32) | Major Consortium Study |
| rs1535 | FADS2 | GWAS association (p=3.0e-31) | Major Consortium Study |
| rs261290 | — | GWAS association (p=2.0e-29) | Major Consortium Study |
| rs56094641 | — | GWAS association (p=1.0e-28) | Major Consortium Study |
| rs2138161 | — | GWAS association (p=8.0e-28) | Major Consortium Study |
| rs998584 | POLR1C | GWAS association (p=4.0e-27) | Major Consortium Study |
| rs28597716 | — | GWAS association (p=1.0e-24) | Major Consortium Study |
| rs3764261 | — | GWAS association (p=3.0e-13) | Major Consortium Study |
| rs12056034 | — | GWAS association (p=8.0e-22) | Major Consortium Study |
| rs66922415 | — | GWAS association (p=6.0e-19) | Major Consortium Study |
| rs2925979 | CMIP | GWAS association (p=3.0e-18) | Major Consortium Study |
| rs7124681 | — | GWAS association (p=3.0e-17) | Major Consortium Study |
| rs11206374 | — | GWAS association (p=4.0e-17) | Major Consortium Study |
| rs61789601 | — | GWAS association (p=8.0e-17) | Major Consortium Study |
| rs173539 | — | GWAS association (p=1.0e-16) | Major Consortium Study |
| rs11429307 | — | GWAS association (p=4.0e-16) | Major Consortium Study |
| rs11754773 | — | GWAS association (p=5.0e-16) | Major Consortium Study |
| rs1260326 | GCKR | GWAS association (p=7.0e-16) | Major Consortium Study |
| rs139974673 | — | GWAS association (p=1.0e-15) | Major Consortium Study |
| rs9987289 | LOC157273 | GWAS association (p=4.0e-08) | Major Consortium Study |
| rs1800961 | HNF4A | GWAS association (p=1.0e-14) | Major Consortium Study |
| rs10822155 | JMJD1C | GWAS association (p=2.0e-14) | Major Consortium Study |
| rs12599637 | — | GWAS association (p=5.0e-14) | Major Consortium Study |
| rs638714 | — | GWAS association (p=1.0e-13) | Major Consortium Study |
| rs632057 | — | GWAS association (p=5.0e-13) | Major Consortium Study |
| rs10260148 | LOC105375508 | GWAS association (p=7.0e-13) | Major Consortium Study |
| rs114165349 | — | GWAS association (p=2.0e-12) | Major Consortium Study |
| rs9939224 | CETP | GWAS association (p=7.0e-12) | Major Consortium Study |
| rs10187501 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs1532127 | ZC3H4 | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs301 | LPL | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs7239575 | NPC1 | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs10830956 | — | GWAS association (p=5.0e-11) | Major Consortium Study |
| rs10049088 | — | GWAS association (p=5.0e-11) | Major Consortium Study |
| rs1009360 | — | GWAS association (p=5.0e-11) | Major Consortium Study |
| rs7660883 | AFF1 | GWAS association (p=6.0e-11) | Major Consortium Study |
| rs11075253 | PDXDC1 | GWAS association (p=7.0e-11) | Major Consortium Study |
| rs1534696 | — | GWAS association (p=9.0e-11) | Major Consortium Study |
| rs7563362 | — | GWAS association (p=1.0e-10) | Major Consortium Study |
| rs563296 | — | GWAS association (p=2.0e-10) | Major Consortium Study |
| rs9378248 | HLA-B | GWAS association (p=2.0e-10) | Major Consortium Study |
| rs1023193 | TYRO3 | GWAS association (p=2.0e-10) | Major Consortium Study |
| rs13107325 | SLC39A8 | GWAS association (p=4.0e-10) | Major Consortium Study |
| rs764311894 | — | GWAS association (p=5.0e-10) | Major Consortium Study |
| rs779518917 | — | GWAS association (p=5.0e-10) | Major Consortium Study |
| rs35661464 | NAALADL1 | GWAS association (p=5.0e-10) | Major Consortium Study |
| rs748326686 | — | GWAS association (p=6.0e-10) | Major Consortium Study |
| rs577721086 | RSPO3 | GWAS association (p=9.0e-10) | Major Consortium Study |
| rs537069642 | — | GWAS association (p=1.0e-09) | Major Consortium Study |
| rs76376137 | — | GWAS association (p=1.0e-09) | Major Consortium Study |
| rs2197089 | — | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs1387153 | — | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs295 | LPL | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs2266788 | ZPR1 | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs10913469 | SEC16B | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs56133711 | BDNF | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs3814883 | TAOK2 | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs56282717 | KCNH2 | GWAS association (p=2.0e-09) | Major Consortium Study |
| rs12945575 | COASY | GWAS association (p=3.0e-09) | Major Consortium Study |
| rs2306363 | — | GWAS association (p=3.0e-09) | Major Consortium Study |
| rs781006834 | — | GWAS association (p=3.0e-09) | Major Consortium Study |
| rs10790162 | BUD13 | GWAS association (p=5.0e-09) | Major Consortium Study |
| rs11751347 | — | GWAS association (p=5.0e-09) | Major Consortium Study |
| rs73123462 | — | GWAS association (p=5.0e-09) | Major Consortium Study |
| rs62107261 | LOC124905962 | GWAS association (p=5.0e-09) | Major Consortium Study |
| rs3808439 | — | GWAS association (p=5.0e-09) | Major Consortium Study |
| rs11820589 | BUD13 | GWAS association (p=6.0e-09) | Major Consortium Study |
| rs56959712 | HCAR2 | GWAS association (p=6.0e-09) | Major Consortium Study |
| rs560001710 | — | GWAS association (p=7.0e-09) | Major Consortium Study |
| rs779470261 | — | GWAS association (p=7.0e-09) | Major Consortium Study |
| rs5789783 | — | GWAS association (p=8.0e-09) | Major Consortium Study |
| rs3949781 | — | GWAS association (p=8.0e-09) | Major Consortium Study |
| rs11871285 | BPTF | GWAS association (p=8.0e-09) | Major Consortium Study |
| rs6535703 | — | GWAS association (p=9.0e-09) | Major Consortium Study |
| rs2043085 | — | GWAS association (p=1.0e-08) | Major Consortium Study |
| rs12286037 | ZPR1 | GWAS association (p=1.0e-08) | Major Consortium Study |
| rs58175144 | — | GWAS association (p=1.0e-08) | Major Consortium Study |
| rs7188873 | — | GWAS association (p=1.0e-08) | Major Consortium Study |
| rs5021727 | — | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs1105654 | LOC105372112 | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs12752223 | — | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs140628616 | — | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs9971210 | — | GWAS association (p=2.0e-08) | Major Consortium Study |
| rs1441756 | — | GWAS association (p=3.0e-08) | Major Consortium Study |
| rs10954772 | — | GWAS association (p=3.0e-08) | Major Consortium Study |
| rs12472667 | ERICH2 | GWAS association (p=3.0e-08) | Major Consortium Study |
| rs1143015 | — | GWAS association (p=3.0e-08) | Major Consortium Study |
| rs11789603 | ABCA1 | GWAS association (p=4.0e-08) | Major Consortium Study |
| rs9332817 | — | GWAS association (p=4.0e-08) | Major Consortium Study |
Showing the top 100 of 701 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.