rs5021727

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

free cholesterol measurement, blood VLDL cholesterol amount, chylomicron amount

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele A

OR 0.02

p 2.0e-9

N 115,082

Large GWAS

European

total cholesterol measurement, blood VLDL cholesterol amount, chylomicron amount

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele A

OR 0.02

p 1.0e-8

N 115,082

Large GWAS

European

metabolic syndrome

Lind L et al. “Genome-Wide Association Study of the Metabolic Syndrome in UK Biobank.” Metabolic Syndrome and Related Disorders 17(10):505-511 (2019)

Allele G

OR 0.04

p 2.0e-8

N 291,107

Major Consortium StudyLarge GWAS

European

cholesteryl ester measurement, blood VLDL cholesterol amount, chylomicron amount

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele A

OR 0.02

p 4.0e-8

N 115,082

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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