VTCN1
V-set domain containing T cell activation inhibitor 1
Summary
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Known Variants8 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs13505 | 1:117,686,492 | C/A | 3 prime UTR variant | — |
| rs10754339 | 1:117,690,272 | G/A | regulatory region variant | — |
| rs2358817 | 1:117,690,758 | C/T | regulatory region variant | — |
| rs10801935 | 1:117,721,887 | C/A | intron variant | — |
| rs1113673 | 1:117,726,785 | C/A | intron variant | — |
| rs72699165 | 1:117,729,516 | T/C | intron variant | — |
| rs12046117 | 1:117,751,365 | C/T | intron variant | — |
| rs3738414 | 1:117,753,528 | G/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.