rs10754339
This is a regulatory region variant variant in the VTCN1 gene.
▶Research that mentions this SNP (1)
▶miR‐30a promoter variation contributes to the increased risk of colorectal cancer in an Iranian populationMeta-analysisN=5,670Hossein Sadeghi et al.(2019)· Journal of Cellular Biochemistry
A meta-analysis investigating the association of B7-H4 gene rs10754339 (A/G) and miR-125a gene rs12976445 (T/C) with cancer susceptibility across multiple cancer types. The study included original case-control data from 1,490 Chinese cancer patients (liver, lung, and gastric cancers) and 800 controls, plus meta-analysis of 8 studies for rs10754339 and 8 studies for rs12976445. Results showed rs10754339 A-allele was protective against overall cancer (OR 0.78, 95% CI 0.66-0.93) and breast cancer specifically (OR 0.73, 95% CI 0.64-0.85) in Chinese populations, while rs12976445 T-allele increased cancer risk overall (OR 1.28, 95% CI 1.13-1.45 in Chinese population).
About VTCN1
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
View all VTCN1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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