WASF3

WASP family member 3

Summary

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]

Known Variants37 total

rsidPosition (GRCh37)AllelesClassClinVar
rs133101213:27,115,424G/Tintergenic variant
rs11692363013:27,131,971C/Tregulatory region variant
rs75892865213:27,216,513G/Auncertain significance
rs14397055413:27,216,516A/Guncertain significance
rs77405902013:27,216,523G/Auncertain significance
rs20221448113:27,239,155T/Cbenign
rs254276255913:27,239,170C/Tuncertain significance
rs131542515513:27,239,200A/Guncertain significance
rs76254200913:27,239,211C/Auncertain significance
rs951231813:27,239,255G/Tuncertain significance
rs254276304113:27,239,264T/Cuncertain significance
rs91305593813:27,239,267A/Guncertain significance
rs37373642513:27,241,730C/Guncertain significance
rs20168399413:27,246,082C/Guncertain significance
rs75673373213:27,250,713C/Tuncertain significance
rs128174659213:27,255,196A/Guncertain significance
rs14577494813:27,255,226C/Tuncertain significance
rs14853280213:27,255,300G/Auncertain significance
rs14142936113:27,255,386G/Alikely benign
rs55625132813:27,255,391C/Guncertain significance
rs14514755313:27,255,394C/Tuncertain significance
rs15132214513:27,255,402C/Glikely benign
rs733283813:27,255,437G/Abenign
rs75941088913:27,256,797C/Tuncertain significance
rs13855471313:27,256,803C/Tuncertain significance
rs14130577413:27,256,902C/Glikely benign
rs74706632313:27,256,944C/Tuncertain significance
rs53344635713:27,256,950C/Tuncertain significance
rs37351957313:27,256,953C/Tuncertain significance
rs188328052413:27,256,982C/Guncertain significance
rs20160159113:27,256,985G/Cuncertain significance
rs37655557213:27,257,015A/Guncertain significance
rs250018446013:27,257,021G/Cuncertain significance
rs13808090213:27,257,069A/Gbenign
rs75192975013:27,257,099G/Auncertain significance
rs75836953813:27,259,872C/Tuncertain significance
rs7816412213:27,259,976C/Tbenign

Gene information from NCBI Gene. Variant classifications from ClinVar.