WDR1

WD repeat domain 1

Summary

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Known Variants434 total

rsidPosition (GRCh37)AllelesClassClinVar
rs25473397394:10,077,003C/T—likely benign
rs25473397534:10,077,015G/A—uncertain significance
rs7637491844:10,077,026G/C—likely benign
rs3728385744:10,077,028C/G—uncertain significance
rs7570421434:10,077,041G/A—likely benign
rs3767464584:10,077,047C/T—likely benign
rs25473398074:10,077,050G/A—likely benign
rs3771078014:10,077,056C/T—likely benign
rs17647651914:10,077,061G/T—uncertain significance
rs3705085084:10,077,064C/T—uncertain significance
rs355455234:10,077,065G/A—likely benign
rs17647664924:10,077,108T/A—pathogenic
rs12166882164:10,077,115A/C—likely benign
rs1489823534:10,077,120G/A—likely benign
rs14676345434:10,077,122G/A—likely benign
rs7692348064:10,077,126A/G—likely benign
rs3749744994:10,078,918C/T—likely benign
rs7454759124:10,078,919G/A—likely benign
rs7796129914:10,078,920G/A—benign
rs7719389104:10,078,950C/T—likely benign
rs7540622204:10,078,972T/C—uncertain significance
rs12478479344:10,078,974C/T—likely benign
rs17648381024:10,078,977C/T—uncertain significance
rs25473423994:10,078,979T/C—uncertain significance
rs7664570144:10,078,994C/T—uncertain significance
rs7589260924:10,078,995G/A—likely benign
rs7780723244:10,078,998G/C—likely benign
rs12911295314:10,079,001A/G—likely benign
rs13824062114:10,079,034G/C—likely benign
rs7797438114:10,079,036C/G—uncertain significance
rs25473424794:10,079,049G/T—uncertain significance
rs3696758164:10,079,055A/G—likely benign
rs13123789354:10,079,058A/G—likely benign
rs25473425314:10,079,063C/G—uncertain significance
rs3744534054:10,079,067G/A—likely benign
rs25473425604:10,079,080C/A—likely benign
rs12443299864:10,079,082G/C—likely benign
rs25473425764:10,079,083G/T—likely benign
rs789386324:10,079,084T/A—benign
rs7596886154:10,079,087A/C—likely benign
rs5751297854:10,079,091C/G—likely benign
rs3762363544:10,079,364C/T—likely benign
rs7698769324:10,079,365G/A—likely benign
rs7757396464:10,079,367C/T—likely benign
rs3706201434:10,079,368G/A—likely benign
rs341938554:10,079,377C/T—likely benign
rs1818405434:10,079,378G/A—benign
rs3761785904:10,079,380G/A—likely benign
rs7565475054:10,079,385C/T—uncertain significance
rs12235905894:10,079,386G/A—likely benign
rs7649655964:10,079,390G/A—uncertain significance
rs14800160604:10,079,395G/A—likely benign
rs5345127234:10,079,404T/C—likely benign
rs7774389524:10,079,410C/T—likely benign
rs7571709264:10,079,421C/T—uncertain significance
rs3708839154:10,079,422G/A—likely benign
rs5475261914:10,079,425G/A—likely benign
rs7696890374:10,079,431C/T—likely benign
rs7802518324:10,079,434G/A—likely benign
rs7495200554:10,079,442C/T—uncertain significance
rs7686687934:10,079,443G/A—likely benign
rs5681661674:10,079,446G/A—likely benign
rs5355844154:10,079,449G/A—likely benign
rs14475074024:10,079,455G/A—likely benign
rs7609385634:10,079,463C/T—uncertain significance
rs11637766054:10,079,464G/A—likely benign
rs14230712664:10,079,467G/A—likely benign
rs5503959124:10,079,473G/A—likely benign
rs25473439304:10,079,485C/T—likely benign
rs3745197584:10,079,488T/C—likely benign
rs25473439514:10,079,490G/A—likely benign
rs17648609274:10,079,491G/T—likely benign
rs9279072924:10,079,505C/T—uncertain significance
rs3685160204:10,079,506C/G—uncertain significance
rs1868890664:10,079,513G/A—likely benign
rs5727607904:10,079,519C/T—uncertain significance
rs13825378334:10,079,521C/T—uncertain significance
rs12498832424:10,079,533C/T—likely benign
rs7481607834:10,079,541C/T—uncertain significance
rs7735212214:10,079,545G/C—likely benign
rs7612571734:10,079,547C/T—uncertain significance
rs2010751234:10,079,548G/A—likely benign
rs7771671164:10,079,554C/T—likely benign
rs3751750734:10,079,555G/A—likely benign
rs25473441344:10,079,560G/A—likely benign
rs7638168914:10,079,563C/G—likely benign
rs25473441534:10,079,568A/G—likely benign
rs12085727914:10,079,569G/A—likely benign
rs22414694:10,080,462A/C—benign
rs3753398414:10,080,495G/A—likely benign
rs15605272744:10,080,497G/A—likely benign
rs25473458084:10,080,500A/G—likely benign
rs3741229964:10,080,507C/T—likely benign
rs5380568534:10,080,508G/A—likely benign
rs13606124274:10,080,525A/G—likely benign
rs3682551824:10,080,526T/C—conflicting classifications of pathogenicity
rs2008618124:10,080,534G/A—uncertain significance
rs7586761584:10,080,542G/A—likely benign
rs2016877634:10,080,544C/T—uncertain significance
rs3698178874:10,080,545G/A—likely benign

Showing 100 of 434 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.

WDR1 — WD repeat domain 1