rs34193855

This variant is located in the WDR1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

urate measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.37
p 2.0e-196
N 355,426
Major Consortium StudyLarge GWAS
multi-ancestry
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ClinVar annotation

Likely Benign★★★☆
4 submitters2 publications

not provided; Uterine carcinosarcoma; Thymoma; Thyroid cancer, nonmedullary, 1; Acute myeloid leukemia; Chronic lymphocytic leukemia/small lymphocytic lymphoma; Familial pancreatic carcinoma; Malignant lymphoma, large B-cell, diffuse; Colorectal cancer; Ovarian serous cystadenocarcinoma; Hepatocellular carcinoma; Lung cancer; Colon adenocarcinoma; Sarcoma; Nonpapillary renal cell carcinoma; Cervical cancer

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About WDR1

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

View all WDR1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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