XAGE3
X antigen family member 3
Summary
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
Known Variants5 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs186994588 | X:52,893,810 | C/T | — | uncertain significance |
| rs1307924656 | X:52,893,827 | T/A | — | uncertain significance |
| rs1556784457 | X:52,895,555 | C/T | — | uncertain significance |
| rs368718593 | X:52,895,561 | C/T | — | likely benign |
| rs2807031 | X:52,896,949 | C/T | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.