ZFP36L2

ZFP36 like 2 zinc finger CCCH-type

Summary

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]

Known Variants58 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1367173	2:43,449,385	C/G	—	—
rs2466074758	2:43,451,562	T/G	—	uncertain significance
rs1054059394	2:43,451,653	G/C	—	uncertain significance
rs1249302931	2:43,451,673	G/A	—	uncertain significance
rs1179958520	2:43,451,685	C/G	—	uncertain significance
rs955034240	2:43,451,711	G/A	—	uncertain significance
rs369421544	2:43,451,716	C/T	—	likely benign
rs768383040	2:43,451,738	C/A	—	uncertain significance
rs773123280	2:43,451,755	C/G	—	uncertain significance
rs759629300	2:43,451,766	G/A	—	uncertain significance
rs866804302	2:43,451,783	G/A	—	uncertain significance
rs1344468585	2:43,451,814	C/G	—	uncertain significance
rs1422734354	2:43,451,852	G/A	—	uncertain significance
rs777385119	2:43,451,853	C/T	—	uncertain significance
rs764688757	2:43,451,876	G/A	—	uncertain significance
rs769881803	2:43,451,892	C/A	—	uncertain significance
rs761958630	2:43,451,900	G/T	—	uncertain significance
rs761125625	2:43,451,902	C/T	—	likely benign
rs1296052564	2:43,451,954	G/A	—	uncertain significance
rs149290349	2:43,451,957	G/A	—	benign
rs772208081	2:43,451,958	C/T	—	uncertain significance
rs763592426	2:43,451,976	C/T	—	uncertain significance
rs1375456352	2:43,451,979	A/G	—	uncertain significance
rs754906682	2:43,451,996	G/C	—	uncertain significance
rs2466077305	2:43,452,010	C/T	—	likely benign
rs373995498	2:43,452,021	A/C	—	pathogenic
rs368436754	2:43,452,108	G/A	—	likely benign
rs780478324	2:43,452,113	G/A	—	uncertain significance
rs1048207781	2:43,452,128	C/G	—	uncertain significance
rs890439531	2:43,452,129	C/G	—	uncertain significance
rs7933	2:43,452,183	A/G	—	benign
rs2466077921	2:43,452,191	C/T	—	uncertain significance
rs745472270	2:43,452,204	G/A	—	uncertain significance
rs761747459	2:43,452,222	C/G	—	uncertain significance
rs201694029	2:43,452,286	G/C	—	likely benign
rs8098	2:43,452,334	G/A	—	benign
rs759784530	2:43,452,389	C/G	—	uncertain significance
rs752046397	2:43,452,412	C/A	—	likely benign
rs754529710	2:43,452,437	T/C	—	uncertain significance
rs776760038	2:43,452,454	C/T	—	likely benign
rs752332320	2:43,452,499	C/G	—	uncertain significance
rs76867290	2:43,452,608	A/T	—	benign
rs762367560	2:43,452,623	C/T	—	uncertain significance
rs748333896	2:43,452,647	C/T	—	uncertain significance
rs776988707	2:43,452,656	G/A	—	uncertain significance
rs1392388641	2:43,452,657	T/C	—	likely benign
rs369626026	2:43,452,664	G/A	—	likely benign
rs1667073348	2:43,452,666	C/T	—	uncertain significance
rs1027565558	2:43,452,669	C/T	—	uncertain significance
rs933129143	2:43,452,689	C/T	—	uncertain significance
rs200295188	2:43,452,693	C/T	—	uncertain significance
rs781621391	2:43,452,707	G/T	—	uncertain significance
rs1470276604	2:43,452,725	C/T	—	uncertain significance
rs199815762	2:43,452,755	G/A	—	uncertain significance
rs201963284	2:43,452,757	A/C	—	benign
rs761844244	2:43,452,833	C/A	—	uncertain significance
rs745522686	2:43,452,855	T/C	—	uncertain significance
rs112694524	2:43,453,721	G/A	regulatory region variant	—

Gene information from NCBI Gene. Variant classifications from ClinVar.