ZFYVE1
zinc finger FYVE-type containing 1
Summary
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Known Variants29 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs147735924 | 14:73,437,744 | T/A | — | uncertain significance |
| rs760423155 | 14:73,442,294 | C/T | — | uncertain significance |
| rs1367494466 | 14:73,442,404 | T/C | — | uncertain significance |
| rs2504352504 | 14:73,444,640 | G/A | — | uncertain significance |
| rs148974502 | 14:73,444,942 | C/T | — | uncertain significance |
| rs780097110 | 14:73,445,615 | C/T | — | uncertain significance |
| rs2535922 | 14:73,447,240 | A/T | — | — |
| rs141670780 | 14:73,448,561 | T/C | — | uncertain significance |
| rs2504367343 | 14:73,448,577 | C/G | — | uncertain significance |
| rs142964507 | 14:73,460,009 | G/A | — | uncertain significance |
| rs370188500 | 14:73,460,020 | C/T | — | uncertain significance |
| rs145493368 | 14:73,464,525 | C/T | — | uncertain significance |
| rs1893782571 | 14:73,464,560 | A/G | — | uncertain significance |
| rs774717092 | 14:73,464,804 | C/T | — | uncertain significance |
| rs114645045 | 14:73,464,916 | G/T | — | benign |
| rs868547445 | 14:73,465,027 | C/A | — | likely benign |
| rs2504460593 | 14:73,490,735 | T/C | — | uncertain significance |
| rs34303517 | 14:73,490,752 | G/A | — | benign |
| rs1217351378 | 14:73,490,882 | T/C | — | uncertain significance |
| rs2504461271 | 14:73,490,969 | C/G | — | uncertain significance |
| rs756485596 | 14:73,490,985 | T/G | — | uncertain significance |
| rs767643342 | 14:73,491,047 | T/C | — | uncertain significance |
| rs765709384 | 14:73,491,065 | C/T | — | uncertain significance |
| rs368087773 | 14:73,491,066 | G/A | — | uncertain significance |
| rs373998897 | 14:73,491,081 | C/T | — | uncertain significance |
| rs552662436 | 14:73,491,150 | C/T | — | uncertain significance |
| rs143632615 | 14:73,491,189 | T/C | — | uncertain significance |
| rs1157394407 | 14:73,491,200 | G/A | — | uncertain significance |
| rs61988079 | 14:73,494,283 | G/A | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.