rs10008492

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

C-reactive protein measurement

Said S et al. “Genetic analysis of over half a million people characterises C-reactive protein loci.” Nature Communications 13(1):2198 (2022)
Allele T
OR 0.01
p 1.0e-10
N 575,531
Large GWAS
European
Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)
Allele T
OR 0.01
p 6.0e-10
N 575,531
Large GWAS
European
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Research that mentions this SNP (1)

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Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses
Meta-analysisN=11,930Jodie N. Painter et al.(2018)· Cancer Medicine

Cross-disease GWAS meta-analysis of endometriosis and endometrial cancer identified moderate genetic correlation (rg=0.23, P=9.3×10⁻³) and significant SNP pleiotropy between the two diseases. Meta-analysis of 3,194 endometriosis cases and 5,330 endometrial cancer cases (7 datasets) identified 13 replicated loci, with rs2475335 in PTPRD showing genomewide significance (P=4.9×10⁻⁸, OR=1.11, 95% CI=1.07-1.15). PTPRD acts in the STAT3 pathway implicated in both diseases.

Traits studied:Endometrial cancerEndometriosis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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