rs10058728

This is a intron variant variant in the CSNK1A1 gene.

▶

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

esophageal carcinoma

Wu C et al. “Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.” Nature Genetics 43(7):679-84 (2011)

Allele T

OR 2.04

p 5.0e-9

N 4,075

Large GWAS

East Asian

About CSNK1A1

Enables protein serine/threonine kinase activity. Involved in several processes, including intermediate filament cytoskeleton organization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of signal transduction. Located in cytoskeleton and nucleus. Part of beta-catenin destruction complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Jul 2025]

View all CSNK1A1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Loading comments…