rs1008058

This variant is located in the PRDM6 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systolic blood pressure

Surendran P et al. “Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.” Nature Genetics 48(10):1151-1161 (2016)

Allele A

OR 0.50

p 3.0e-9

N 192,763

Large GWAS

multi-ancestry

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ClinVar annotation

Benign

1 submitter

PRDM6-related disorder

View on ClinVar →

About PRDM6

The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. Family members contain a PR domain and multiple zinc-finger domains. The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. Mutations in this gene result in patent ductus arteriosus 3 (PDA3). [provided by RefSeq, Apr 2017]

View all PRDM6 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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