rs10086908

This is a intron variant variant in the LOC105375751 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate carcinoma

Takata R et al. “12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.” Nature Communications 10(1):4422 (2019)
Allele T
OR 1.27
p 7.0e-14
N 15,770
Large GWAS
East Asian
Hoffmann TJ et al. “A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.” Cancer Discovery 5(8):878-91 (2015)
Allele T
OR 1.17
p 2.0e-10
N 46,378
Large GWAS
multi-ancestry

cancer

Ahmed M et al. “Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology.” Communications Biology 5(1):614 (2022)
Allele C
OR —
β 0.005
p 2.0e-10
N 238,404
Major Consortium StudyLarge GWAS
European
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Research that mentions this SNP (3)

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Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases
AssociationN=18,343Brian T. Helfand et al.(2015)· Human Genetics

A case-case association study of 18,343 prostate cancer patients (16,515 European, 1,828 African-American) evaluating 36 validated PC-risk SNPs found that rs2735839 (G allele) on chromosome 19q13 in the KLK3 gene was significantly and inversely associated with aggressive disease and high Gleason scores in both populations (p = 9.343 × 10⁻⁸ overall, p = 1.042 × 10⁻⁵ European, p = 2.0 × 10⁻⁴ African-American).

Traits studied:Gleason scoreProstate cancer aggressivenessProstate cancer high-grade disease
PubMedDOIMetascience Observatory
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Meta‐analysis of genome‐wide and replication association studies on prostate cancer
AssociationN=916Hong Liu et al.(2011)· The Prostate

A case-control study of 489 prostate cancer cases and 427 controls in a New Zealand Caucasian population examined 15 chromosome 8q24 SNPs. Four SNPs showed statistically significant associations with prostate cancer risk: rs10086908 (T allele, OR=1.64), rs16901979 (A allele, OR=2.58), rs1447295 (A allele, OR=1.70), and rs4242382 (A allele, OR=1.60). A weighted genetic risk score based on all 15 SNPs was significantly associated with prostate cancer risk (OR=1.10), with smoking contributing additional risk.

Traits studied:Prostate cancer
PubMedDOIMetascience Observatory
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Prostate cancer risk‐associated variants reported from genome‐wide association studies: Meta‐analysis and their contribution to genetic Variation
Meta-analysisN=600,000Kim ST et al.(2010)· The Prostate

This meta-analysis of genome-wide association studies identified 30 prostate cancer risk-associated SNPs in Caucasian populations. The SNPs had odds ratios ranging from 1.12-1.47, except rs16901979 (OR=1.80). These 30 SNPs collectively explained approximately 13.5% of the total genetic variance in prostate cancer risk, with individual SNPs explaining 0.2-0.9% of variance.

Traits studied:Prostate cancer risk
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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