rs10105606

This is a downstream gene variant variant.

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GWAS Catalog Trait Associations (12)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

triglyceride measurement

Waterworth DM et al. “Genetic variants influencing circulating lipid levels and risk of coronary artery disease.” Arteriosclerosis, Thrombosis, and Vascular Biology 30(11):2264-76 (2010)
Allele C
OR 0.07
p 4.0e-26
N 17,723
Large GWAS
multi-ancestry

triacylglycerol 56:6 measurement

Ottensmann L et al. “Genome-wide association analysis of plasma lipidome identifies 495 genetic associations.” Nature Communications 14(1):6934 (2023)
Allele A
OR 0.13
p 2.0e-12
N 7,151
Large GWAS
European

triacylglycerol 52:3 measurement

Ottensmann L et al. “Genome-wide association analysis of plasma lipidome identifies 495 genetic associations.” Nature Communications 14(1):6934 (2023)
Allele A
OR 0.13
p 3.0e-12
N 7,173
Large GWAS
European

triacylglycerol 52:4 measurement

Ottensmann L et al. “Genome-wide association analysis of plasma lipidome identifies 495 genetic associations.” Nature Communications 14(1):6934 (2023)
Allele A
OR 0.13
p 1.0e-11
N 7,174
Large GWAS
European

triacylglycerol 54:4 measurement

Ottensmann L et al. “Genome-wide association analysis of plasma lipidome identifies 495 genetic associations.” Nature Communications 14(1):6934 (2023)
Allele A
OR 0.12
p 2.0e-11
N 7,165
Large GWAS
European

triacylglycerol 54:5 measurement

Ottensmann L et al. “Genome-wide association analysis of plasma lipidome identifies 495 genetic associations.” Nature Communications 14(1):6934 (2023)
Allele A
OR 0.12
p 4.0e-10
N 7,146
Large GWAS
European

triacylglycerol 54:3 measurement

Ottensmann L et al. “Genome-wide association analysis of plasma lipidome identifies 495 genetic associations.” Nature Communications 14(1):6934 (2023)
Allele A
OR 0.11
p 1.0e-9
N 7,162
Large GWAS
European
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Research that mentions this SNP (1)

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Common genetic variants associated with lipid profiles in a Chinese pediatric population
AssociationN=3,503Yue Shen et al.(2013)· Human Genetics

This study tested seven SNPs from European lipid-associated loci in 3,503 Chinese school-age children and found that six SNPs (rs2144300, rs1260333, rs1260326, rs10105606, rs1748195, rs964184) showed significant associations with triglyceride levels (p < 0.05 FDR-corrected), while three SNPs were associated with total cholesterol and four with LDL-cholesterol. Three SNPs (rs1260333 OR=0.82, rs1260326 OR=0.82, rs964184 OR=1.36) showed strong associations with dyslipidemia risk, demonstrating that lipid-susceptibility variants identified in European populations have similar effects in Chinese children.

Traits studied:DyslipidemiaHDL-cholesterolLDL-cholesterolTotal cholesterolTriglycerides
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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