rs10149470

This variant is located in the LOC124903392 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

major depressive disorder

Howard DM et al. “Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.” Nature Neuroscience 22(3):343-352 (2019)
Allele G
OR 1.02
p 7.0e-22
N 807,553
Meta-analysisLarge GWAS
European
Als TD et al. “Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.” Nature Medicine 29(7):1832-1844 (2023)
Allele G
OR 0.02
p 2.0e-16
N 1,349,887
Large GWAS
European
Wray NR et al. “Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.” Nature Genetics 50(5):668-681 (2018)
Allele G
OR 1.03
p 3.0e-9
N 480,359
Large GWAS
European

intelligence

Hill WD et al. “A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.” Molecular Psychiatry 24(2):169-181 (2019)
Allele A
OR 0.02
p 5.0e-11
N 248,482
Large GWAS
European
Coleman JRI et al. “Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.” Molecular Psychiatry 24(2):182-197 (2019)
Allele A
OR 5.49
p 4.0e-8
N 87,740
Meta-analysisLarge GWAS
European

autism spectrum disorder, major depressive disorder

Grove J et al. “Identification of common genetic risk variants for autism spectrum disorder.” Nature Genetics 51(3):431-444 (2019)
Allele A
OR 0.05
p 9.0e-9
N 470,365
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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