rs1021363

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

major depressive disorder

Als TD et al. “Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.” Nature Medicine 29(7):1832-1844 (2023)
Allele A
OR 0.03
p 2.0e-25
N 1,349,887
Large GWAS
European
Meng X et al. “Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.” Nature Genetics 56(2):222-233 (2024)
Allele A
OR 0.03
p 1.0e-18
N 1,820,689
Large GWAS
multi-ancestry
Howard DM et al. “Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.” Nature Neuroscience 22(3):343-352 (2019)
Allele A
OR 1.02
p 4.0e-23
N 807,553
Meta-analysisLarge GWAS
European
Giannakopoulou O et al. “The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.” Jama Psychiatry 78(11):1258-1269 (2021)
Allele A
OR 0.01
p 5.0e-9
N 694,747
Large GWAS
multi-ancestry
Yao X et al. “Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.” Translational Psychiatry 11(1):69 (2021)
Allele A
OR 0.03
p 2.0e-14
N 500,199
Large GWAS
European
Howard DM et al. “Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.” Nature Communications 9(1):1470 (2018)
Allele A
OR 0.01
p 1.0e-8
N 322,580
Major Consortium StudyLarge GWAS
European

depressive symptom measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele G
OR 0.01
p 1.0e-13
N 1,067,913
Large GWAS
European

autism spectrum disorder

Yao X et al. “Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.” Translational Psychiatry 11(1):69 (2021)
Allele A
OR 0.07
p 1.0e-8
N 46,350
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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