rs10401176

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele T

OR 0.02

p 2.0e-20

N 1,486,094

Large GWAS

European

Alzheimer's disease biomarker measurement

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele T

OR 0.02

p 9.0e-15

N 568,836

Large GWAS

European

Alzheimer disease, family history of Alzheimer’s disease

Willett JDS et al. “Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(2):e14592 (2025)

Allele T

OR —

p 2.0e-11

N 404,467

Large GWAS

multi-ancestry

familial hyperlipidemia

Trinder M et al. “Polygenic architecture and cardiovascular risk of familial combined hyperlipidemia.” Atherosclerosis 340:35-43 (2022)

Allele C

OR 0.22

p 4.0e-9

N 349,222

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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