rs10423674

This study examined CRTC1 polymorphisms and their association with body mass index (BMI) and fat mass in psychiatric patients and the general population. The rs3746266A>G variant was significantly associated with lower BMI in psychiatric patients (beta ≈ 1.81-3.87 kg/m², p<0.0001), with the strongest effect in women younger than 45 years. The proxy SNP rs6510997C>T showed associations with fat mass in a large population-based cohort (n=123,865, p=0.01).

A hospital-based case-control study in rural and urban India (1,204 cases; 1,212 controls) examined genetic and lifestyle risk factors for breast cancer. Four SNPs in FGFR2 (rs1219648, rs2420946, rs2981575, rs2981582) showed positive associations with breast cancer (ORs 1.32-1.47). Additional SNPs in obesity and metabolic genes (rs374748 in FBN2, rs2922763 in HNF4G, rs2116830 in KCNMA1, rs11121832 in MTHFR, rs16886165 in MAP3K1, rs11594610 in TCF7L2, rs2274459 in MLN) were associated with increased breast cancer risk. Waist-to-hip ratio ≥0.95 showed strong association (OR 3.78; 95% CI 2.92-4.89), and women living first 20 years in rural areas showed protective effect (OR 0.77).