rs1045643

This is a downstream gene variant variant in the UBN1 gene.

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Research that mentions this SNP (1)

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ABCB1 genetic variation and P-glycoprotein expression/activity in a cohort of Brazilian acute myeloid leukemia patients
AssociationN=109Marcos Antonio Mauricio Scheiner et al.(2012)· Journal of Cancer Research and Clinical Oncology

This study examined the relationship between ABCB1 gene polymorphisms (rs1128503 C1236T and rs1045643 C3435T) and P-glycoprotein expression/activity in 109 Brazilian acute myeloid leukemia (AML) patients. The CC genotype at exon 12 was associated with significantly better 5-year overall survival (p=0.04) and event-free survival (p=0.001), while the TT genotype was associated with poor prognosis. P-glycoprotein expression and activity levels did not significantly correlate with treatment remission rates but showed significant dissociation between expression and activity levels.

Traits studied:Acute myeloid leukemiaEvent-free survivalOverall survivalTreatment response
PubMedDOIMetascience Observatory

About UBN1

Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]

View all UBN1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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