UBN1
ubinuclein 1
Summary
Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]
Known Variants20 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs75588955 | 16:4,899,394 | G/T | upstream gene variant | — |
| rs60135719 | 16:4,899,968 | C/G | — | — |
| rs8056889 | 16:4,903,243 | C/T | intron variant | — |
| rs11862351 | 16:4,903,583 | G/C | — | — |
| rs9745736 | 16:4,905,691 | A/C | — | — |
| rs760598275 | 16:4,908,610 | C/T | — | likely benign |
| rs191701746 | 16:4,910,861 | C/G | — | benign |
| rs114218200 | 16:4,920,841 | G/A | — | benign |
| rs1596515790 | 16:4,921,165 | G/C | — | likely benign |
| rs144134592 | 16:4,924,280 | G/C | — | benign |
| rs143954303 | 16:4,924,334 | T/C | — | benign |
| rs73517087 | 16:4,924,427 | G/A | — | benign |
| rs765004815 | 16:4,924,767 | T/A | missense variant | pathogenic |
| rs146192777 | 16:4,924,905 | G/C | — | benign |
| rs760905886 | 16:4,924,985 | A/G | — | likely benign |
| rs141506746 | 16:4,925,084 | A/C | — | benign |
| rs143113935 | 16:4,926,958 | C/T | — | likely benign |
| rs35657330 | 16:4,927,084 | C/T | — | benign |
| rs150536550 | 16:4,927,462 | G/A | — | benign |
| rs1045643 | 16:4,931,513 | C/T | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.