rs146192777
This variant is located in the UBN1 gene.
▶ClinVar annotation
Benign★★★☆
2 submitters2 publicationsAbout UBN1
Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]
View all UBN1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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