rs1047210

This is a downstream gene variant variant in the TRIM59 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)

Allele A

OR —

p 3.0e-15

N 2,535,601

Large GWAS

multi-ancestry

aging

McCartney DL et al. “Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.” Genome Biology 22(1):194 (2021)

Allele C

OR 0.19

p 5.0e-10

N 34,461

Large GWAS

European

About TRIM59

Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of canonical NF-kappaB signal transduction. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

View all TRIM59 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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