rs10489202

This is a upstream gene variant variant in the MPC2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

schizophrenia

Shi Y et al. “Common variants on 8p12 and 1q24.2 confer risk of schizophrenia.” Nature Genetics 43(12):1224-7 (2011)
Allele A
OR 1.23
p 1.0e-8
N 10,218
Large GWAS
East Asian
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Research that mentions this SNP (1)

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Neural effects of the CSMD1 genome‐wide associated schizophrenia risk variant rs10503253
ReviewEmma J. Rose et al.(2013)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

A comprehensive review of the genetics and epigenetics of schizophrenia, covering candidate gene associations, genome-wide association studies (GWAS), gene expression studies, and epigenetic mechanisms. The review highlights major GWAS findings including associations with CSMD1 (rs10503253), CACNA1C (rs4765905), SLC30A3 (rs11126936, rs11126929), VRK2 (rs2312147), MPC2 (rs10489202), miR-137 (rs1625579), and MKL1 (rs6001946), while discussing the complex polygenic architecture of the disorder with heritability estimated at 81-85%.

Traits studied:Schizophrenia
PubMedDOIMetascience Observatory

About MPC2

Enables identical protein binding activity. Involved in mitochondrial pyruvate transmembrane transport. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2025]

View all MPC2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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