rs10491431

This variant is located in the UGT3A1 gene.

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GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

X-24544 measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele A
OR 0.59
p —
N 14,296
Large GWAS
European

pregnenediol sulfate (C21H34O5S) measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele A
OR 0.26
p 5.0e-47
N 8,260
Large GWAS
European

5alpha-pregnan-diol disulfate measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele A
OR 0.35
p 1.0e-37
N 4,110
Large GWAS
European

pregnenediol disulfate (C21H34O8S2) measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele A
OR 0.22
p 5.0e-31
N 8,245
Large GWAS
European

pregnenolone sulfate measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele A
OR 0.17
p 3.0e-17
N 7,772
Large GWAS
European

pregnanediol-3-glucuronide measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele A
OR 0.16
p 6.0e-13
N 7,905
Large GWAS
European

metabolite measurement

Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele A
OR 0.26
p 2.0e-12
N 4,917
Large GWAS
European

X-11445--5-alpha-pregnan-3beta,20alpha-disulfate measurement

Shin SY et al. “An atlas of genetic influences on human blood metabolites.” Nature Genetics 46(6):543-550 (2014)
Allele A
OR 0.08
p 2.0e-11
N 2,570
Large GWAS
European

liver disease

Pujol Gualdo N et al. “Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses.” Nature Medicine 31(5):1626-1634 (2025)
Allele C
OR 0.80
p 4.0e-9
N 300,553
Large GWAS
European

About UGT3A1

Enables glucuronosyltransferase activity. Part of UDP-N-acetylglucosamine transferase complex. [provided by Alliance of Genome Resources, Jul 2025]

View all UGT3A1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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