Trait
SNPs associated with Liver disease
45 genetic variants across 16 genes have been associated with Liver disease in published research. Key genes include APOE, ARHGEF28, ERLIN1.
Associated variants45 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs28929474 | SERPINA1 | Elevated risk of cirrhosis, fibrosis, and hepatocellular carcinoma | Meta-analysis |
| rs3747207 | PNPLA3 | GWAS association (p=4.0e-78) | Major Consortium Study |
| rs2001846 | — | GWAS association (p=3.0e-46) | Major Consortium Study |
| rs6982502 | — | GWAS association (p=9.0e-45) | Major Consortium Study |
| rs28601761 | — | GWAS association (p=5.0e-44) | Major Consortium Study |
| rs780093 | GCKR | GWAS association (p=2.0e-38) | Major Consortium Study |
| rs1260326 | GCKR | GWAS association (p=3.0e-36) | Major Consortium Study |
| rs780094 | GCKR | GWAS association (p=2.0e-35) | Major Consortium Study |
| rs429358 | APOE | GWAS association (p=2.0e-27) | Major Consortium Study |
| rs5117 | — | GWAS association (p=2.0e-26) | Major Consortium Study |
| rs2642438 | MTARC1 | GWAS association (p=8.0e-26) | Major Consortium Study |
| rs28528308 | — | GWAS association (p=8.0e-20) | Major Consortium Study |
| rs28679728 | — | GWAS association (p=1.0e-19) | Major Consortium Study |
| rs28497720 | MTTP | GWAS association (p=2.0e-16) | Major Consortium Study |
| rs10883451 | ERLIN1 | GWAS association (p=2.0e-15) | Major Consortium Study |
| rs1408579 | ERLIN1 | GWAS association (p=3.0e-15) | Major Consortium Study |
| rs2862954 | ERLIN1 | GWAS association (p=2.0e-14) | Major Consortium Study |
| rs4918727 | — | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs10102352 | — | GWAS association (p=2.0e-12) | Major Consortium Study |
| rs4285810 | — | GWAS association (p=3.0e-12) | Major Consortium Study |
| rs57023984 | — | GWAS association (p=9.0e-12) | Major Consortium Study |
| rs4918722 | GPAM | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs58542926 | TM6SF2 | GWAS association (p=4.0e-119) | Major Consortium Study |
| rs738409 | PNPLA3 | GWAS association (p=9.9e-324) | Major Consortium Study |
| rs10030937 | — | GWAS association (p=4.0e-17) | Major Consortium Study |
| rs10733608 | — | GWAS association (p=5.0e-12) | Major Consortium Study |
| rs112635299 | — | GWAS association (p=2.0e-21) | Major Consortium Study |
| rs71633359 | — | GWAS association (p=2.0e-20) | Major Consortium Study |
| rs887829 | UGT1A1 | GWAS association (p=2.0e-12) | Major Consortium Study |
| rs4803221 | IFNL4 | GWAS association (p=5.0e-15) | Major Consortium Study |
| rs6748810 | — | GWAS association (p=4.0e-76) | Large GWAS |
| rs11977881 | — | GWAS association (p=1.0e-33) | Large GWAS |
| rs10107182 | — | GWAS association (p=9.0e-33) | Large GWAS |
| rs296391 | — | GWAS association (p=5.0e-28) | Large GWAS |
| rs1800961 | HNF4A | GWAS association (p=2.0e-22) | Large GWAS |
| rs72623176 | — | GWAS association (p=9.0e-22) | Large GWAS |
| rs9396784 | LOC102724591 | GWAS association (p=9.0e-17) | Large GWAS |
| rs12984928 | GAPDHS | GWAS association (p=4.0e-16) | Large GWAS |
| rs9645500 | — | GWAS association (p=6.0e-13) | Large GWAS |
| rs7730596 | ARHGEF28 | GWAS association (p=1.0e-11) | Large GWAS |
| rs2788095 | — | GWAS association (p=5.0e-11) | Large GWAS |
| rs34491636 | — | GWAS association (p=4.0e-10) | Large GWAS |
| rs10491431 | UGT3A1 | GWAS association (p=4.0e-09) | Large GWAS |
| rs6788947 | — | GWAS association (p=6.0e-09) | Large GWAS |
| rs75460349 | — | GWAS association (p=4.0e-08) | Large GWAS |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.